Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …

Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have
revolutionized cancer treatment, but further progress is hindered by our limited …

RNA sequencing (RNA-seq) provides an efficient high-throughput technique to robustly
characterize the tumor immune microenvironment (TME). The increasing use of RNA-seq in …

Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …

Cancer cells can leverage several cell-intrinsic and-extrinsic mechanisms to escape
immune system recognition. The inherent complexity of the tumor microenvironment, with its …

Abstract The Tumor Immune Single Cell Hub 2 (TISCH2) is a resource of single-cell RNA-
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …

Background Although immune checkpoint blockade is effective for several malignancies, a
substantial number of patients remain refractory to treatment. The future of immunotherapy …

To elucidate the role of immune cell infiltration as a prognostic signature in solid tumors, we
analyzed immune-function-related genes from four publicly available single-cell RNA-Seq …

Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a
myriad of non-cancerous cell types that together with the extracellular matrix form the tumor …