Artificial intelligence for histology-based detection of microsatellite instability and prediction of response to immunotherapy in colorectal cancer
LA Hildebrand, CJ Pierce, M Dennis, M Paracha… - Cancers, 2021 - mdpi.com
Simple Summary Defects in a DNA repair pathway called mismatch repair (MMR) can lead
to cancer, including colorectal cancer (CRC). The detection of mismatch repair deficiency …
to cancer, including colorectal cancer (CRC). The detection of mismatch repair deficiency …
[HTML][HTML] Deep learning for the detection of microsatellite instability from histology images in colorectal cancer: a systematic literature review
Microsatellite instability (MSI) or deficient mismatch repair (dMMR) is a clinically important
genetic feature affecting 10–15% of colorectal cancer (CRC) patients. Patients with …
genetic feature affecting 10–15% of colorectal cancer (CRC) patients. Patients with …
[HTML][HTML] Artificial intelligence for detection of microsatellite instability in colorectal cancer—a multicentric analysis of a pre-screening tool for clinical application
Background Microsatellite instability (MSI)/mismatch repair deficiency (dMMR) is a key
genetic feature which should be tested in every patient with colorectal cancer (CRC) …
genetic feature which should be tested in every patient with colorectal cancer (CRC) …
Feasibility of deep learning‐based fully automated classification of microsatellite instability in tissue slides of colorectal cancer
SH Lee, IH Song, HJ Jang - International journal of cancer, 2021 - Wiley Online Library
High levels of microsatellite instability (MSI‐H) occurs in about 15% of sporadic colorectal
cancer (CRC) and is an important predictive marker for response to immune checkpoint …
cancer (CRC) and is an important predictive marker for response to immune checkpoint …
Validation of MSIntuit as an AI-based pre-screening tool for MSI detection from colorectal cancer histology slides
C Saillard, R Dubois, O Tchita, N Loiseau… - Nature …, 2023 - nature.com
Abstract Mismatch Repair Deficiency (dMMR)/Microsatellite Instability (MSI) is a key
biomarker in colorectal cancer (CRC). Universal screening of CRC patients for MSI status is …
biomarker in colorectal cancer (CRC). Universal screening of CRC patients for MSI status is …
Deep learning model for the prediction of microsatellite instability in colorectal cancer: a diagnostic study
R Yamashita, J Long, T Longacre, L Peng… - The Lancet …, 2021 - thelancet.com
Background Detecting microsatellite instability (MSI) in colorectal cancer is crucial for clinical
decision making, as it identifies patients with differential treatment response and prognosis …
decision making, as it identifies patients with differential treatment response and prognosis …
[HTML][HTML] Clinical-grade detection of microsatellite instability in colorectal tumors by deep learning
Background & Aims Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR)
in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI …
in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI …
[HTML][HTML] Development and interpretation of a pathomics-based model for the prediction of microsatellite instability in colorectal cancer
Microsatellite instability (MSI) has been approved as a pan-cancer biomarker for immune
checkpoint blockade (ICB) therapy. However, current MSI identification methods are not …
checkpoint blockade (ICB) therapy. However, current MSI identification methods are not …
Development and validation of MRI‐based deep learning models for prediction of microsatellite instability in rectal cancer
W Zhang, H Yin, Z Huang, J Zhao, H Zheng… - Cancer …, 2021 - Wiley Online Library
Background Microsatellite instability (MSI) predetermines responses to adjuvant 5‐
fluorouracil and immunotherapy in rectal cancer and serves as a prognostic biomarker for …
fluorouracil and immunotherapy in rectal cancer and serves as a prognostic biomarker for …
A histology-based model for predicting microsatellite instability in colorectal cancers
A Hyde, D Fontaine, S Stuckless, R Green… - The American journal …, 2010 - journals.lww.com
Identifying colorectal cancers (CRCs) with high levels of microsatellite instability (MSI-H) is
clinically important. MSI-H is a positive prognostic marker for CRC, a predictive marker for …
clinically important. MSI-H is a positive prognostic marker for CRC, a predictive marker for …
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