Schwannomas are tumors of the Schwann cells that cause chronic pain, numbness, and
potentially life-threatening impairment of vital organs. Despite the identification of causative …

Background Inactivation of the NF2 gene predisposes to neurofibromatosis type II and the
development of schwannomas. In vitro studies have shown that loss of NF2 leads to the …

Multiple cancer signalling networks take part in regulatory crosstalks with the Hippo tumour
suppressor pathway through the transcriptional cofactor Yes-associated protein (YAP) …

Malignant mesothelioma (MM) shows frequent inactivation of the neurofibromatosis type 2
(NF2)–tumor-suppressor gene. Recent studies have documented that the Hippo signaling …

The Hippo–YAP pathway has emerged as a major driver of tumorigenesis in many human
cancers. YAP is a transcriptional coactivator and while details of YAP regulation are quickly …

Neurofibromatosis type 2 is a genetic disorder that results in the formation and progressive
growth of schwannomas, ependymomas, and/or meningiomas. The NF2 gene encodes the …

Throughout the last 15 years, the Hippo pathway has been shown to be one of the most
intriguing signaling pathway found to fulfil a crucial role in regulating multiple cellular …

Schwannomas are common, highly morbid and medically untreatable tumors that can arise
in patients with germ line as well as somatic mutations in neurofibromatosis type 2 (NF2) …

Loss of the tumor suppressor merlin causes development of the tumors of the nervous
system, such as schwannomas, meningiomas, and ependymomas occurring spontaneously …

Abstract Neurofibromatosis type 2 (NF2) is an autosomal-dominant multiple neoplasia
syndrome that results from mutations in the NF2 tumor suppressor gene. Patients with NF2 …