Nucleotides are required for a wide variety of biological processes and are constantly
synthesized de novo in all cells. When cells proliferate, increased nucleotide synthesis is …

Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the
aspects of nucleotide metabolism. The book intends to present the chemistry and …

Publisher Summary This chapter discusses that all cells need a balanced supply of
nucleotides as precursors of DNA, RNA, and the nucleotide coenzymes involved in group …

Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies
have shown that abnormal nucleotide metabolism not only accelerates the development of …

Tumor cells increase the use of anabolic pathways to satisfy the metabolic requirements
associated with a high growth rate. Transformed cells take up and metabolize nutrients such …

The effects of several nucleoside triphosphates as activators and inhibitors of the enzymic
reduction of ribonucleoside diphosphates to deoxynucleotides was studied. The enzyme …

Previous work has shown that some cancer cells are highly dependent on serine/glycine
uptake for proliferation. Although serine and glycine can be interconverted and either might …

De novo pyrimidine biosynthesis is activated in proliferating cells in response to an
increased demand for nucleotides needed for DNA synthesis. The pyrimidine biosynthetic …

Transformed cells are characterized by imbalances in metabolic routes. In particular,
different key enzymes of nucleotide metabolism and DNA biosynthesis, such as CTP …

Cellular metabolism has emerged as a major biological node governing cellular behaviour.
Metabolic pathways fuel cellular energy needs, providing basic chemical molecules to …