Abstract Background: Oxygen (O2) homeostasis is an indispensable requirement of
eukaryotes. O2 concentration in cellular milieu is defined as normoxia (∼ 21% O2) …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer
drug target. Many recent studies have provided convincing evidences of strong correlation …

The hypoxic microenvironment is an essential characteristic of most malignant tumors.
Notably, hypoxia-inducible factor-1 alpha (HIF-1α) is a key regulatory factor of cellular …

Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

The complex cross‐talk of intricate intercellular signaling networks between the tumor and
stromal cells promotes cancer progression. Hypoxia is one of the most common conditions …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

Abstract Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator,
which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …

Hypoxia is a condition always present in tumor environment owing to the fast growth of
tumor cells not supported by adequate blood supply. There is increasing evidence that …

Hypoxia‐inducible factors (HIFs) are transcription factors that activate the transcription of
genes necessary to circumvent to hypoxic (low oxygen level) environments. In …