Blood vessels are conduits distributed throughout the body, supporting tissue growth and
homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the …

Skeletal vasculature plays a central role in the maintenance of microenvironments for
osteogenesis and haematopoiesis. In addition to supplying oxygen and nutrients …

During bone development, homeostasis and repair, a dense vascular system provides
oxygen and nutrients to highly anabolic skeletal cells. Characteristic for the vascular system …

In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked
during bone growth and regeneration in bone modeling and during bone homeostasis in …

Angiogenesis, hematopoiesis and osteogenesis are fundamental processes mediating
complex and essential biological functions. In the bone marrow, endothelial cells (ECs) are …

Angiogenesis and bone formation are coupled during skeletal development and fracture
healing. This relationship, although known for some time, has not been properly explored …

Adequate vascularization is an absolute requirement for bone development, growth,
homeostasis, and repair. Endochondral ossification during fetal skeletogenesis is typified by …

Highlights•VEGF is required for both vascular growth and bone formation•Specialized Type
H endothelium regulates osteogenesis through angiocrine signaling•Angiogenesis and …

Angiogenesis plays an important role in physiological bone growth and remodeling, as well
as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor …

Blood vessels serve as a versatile transport system and play crucial roles in organ
development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries …