Metabolic programming is intricately linked to the anti-tumor properties of T cells. To study
the metabolic pathways associated with increased anti-tumor T cell function, we utilized a …

Immune evasion is a critical step of cancer progression that remains a major obstacle for
current T cell–based immunotherapies. Hence, we investigated whether it is possible to …

T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that
distinct metabolic changes impact the activation and differentiation of T cells. Tailoring …

T cells play critical roles in host defenses against cancer. External signals prompt activation
of naïve T cells, triggering modulation of their immune functions. Emerging evidence reveals …

The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

There has been significant progress in utilizing our immune system against cancer, mainly
by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is …

Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated
immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing …

Targeting T cell metabolism is an established method of immunomodulation. Following
activation, T cells engage distinct metabolic programs leading to the uptake and processing …

CD8+ T cells are central players in controlling infections and cancer. Longevity, functionality,
and metabolic fitness are critical determinants of T cell efficacy in cancer immunotherapy …

Cellular metabolism is not only essential for tumor cells to sustain their rapid growth and
proliferation, but also crucial to maintain T cell fitness and robust immunity. Dysregulated …