Recently, we developed a high yield production process for outer membrane particles from
genetically modified bacteria, called Generalized Modules of Membrane Antigens (GMMA) …

Gram-negative bacteria naturally shed particles that consist of outer membrane lipids, outer
membrane proteins, and soluble periplasmic components. These particles have been …

Outer membrane particles from Gram-negative bacteria are attractive vaccine candidates as
they present surface antigens in their natural context. We previously developed a high yield …

Shigellosis is a leading cause of diarrheal disease in low-middle-income countries (LMICs).
Effective vaccines will help to reduce the disease burden, exacerbated by increasing …

Shigellosis remains a major public health problem around the world; it is one of the leading
causes of diarrhoeal disease in low-and middle-income countries, particularly in young …

Shigellosis is a mild-to-severe diarrheal infection, caused by the genus Shigella, and is
responsible for significant morbidity and mortality worldwide. We evaluated the safety and …

Background Shigellosis accounts for substantial morbidity and mortality worldwide and is
the second most common cause of moderate and severe diarrhoea in children. Methods …

Shigella infections are one of the top causes of diarrhea throughout the world, with Shigella
flexneri being predominant in developing countries. Currently, no vaccines are widely …

GMMA are exosomes released from engineered Gram-negative bacteria resembling the
composition of outer membranes. We applied the GMMA technology for the development of …

The investigational Shigella sonnei vaccine (1790GAHB) based on GMMA (generalized
modules for membrane antigens) is immunogenic, with an acceptable safety profile in …