The high density of polymer brushes confers to these coatings unique physicochemical
properties, in particular for the regulation of biomolecular interaction and the design of highly …

Polymer brushes are attractive candidates for the design of gene delivery vectors as they
allow the systematic study of the impact of structural (type, size, and shape of nanomaterials …

Here we describe a core-independent approach enabling the grafting of polymer brushes
from the surface of nanomaterials and microparticles for oligonucleotide delivery. This …

Cylindrical brush polymers constitute promising polymeric drug delivery systems
(nanoDDS). Because of the densely grafted side chains such structures may intrinsically …

A new generation of siRNA nanocarrier with compact, uniform size and excellent colloidal
stability has been developed by combining inorganic nanoparticles with rationally designed …

Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach
their potential. Here, we report on the development of poly (glycoamidoamine) brush …

Cationic polymer brushes are attractive coatings for the development of gene delivery
vectors, owing to the simplicity via which they enable the control of a broad range of design …

Bioengineering immune cells via gene therapy offers treatment opportunities for currently
fatal viral infections. Also cell therapeutics offer most recently a breakthrough technology to …

siRNA nanomedicines can potentially treat many human diseases, but safe and effective
delivery remains a challenge. DNA delivery polymers such as poly (β-amino ester) s …

Delivery is the key challenge for siRNA based therapeutics. Here, we report the
development of new poly (glycoamidoamine) brush nanomaterials for efficient siRNA …