Dynamic antagonism between key repressive pathways maintains the placental epigenome
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …
operate within distinct genomic compartments. In mammals, the majority of the genome is …
Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer
In mammals, the canonical somatic DNA methylation landscape is established upon
specification of the embryo proper and subsequently disrupted within many cancer types …
specification of the embryo proper and subsequently disrupted within many cancer types …
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
JP Reddington, SM Perricone, CE Nestor… - Genome biology, 2013 - Springer
Background DNA methylation and the Polycomb repression system are epigenetic
mechanisms that play important roles in maintaining transcriptional repression. Recent …
mechanisms that play important roles in maintaining transcriptional repression. Recent …
Charting a dynamic DNA methylation landscape of the human genome
DNA methylation is a defining feature of mammalian cellular identity and is essential for
normal development,. Most cell types, except germ cells and pre-implantation embryos …
normal development,. Most cell types, except germ cells and pre-implantation embryos …
H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells
Epigenetic modifications on the chromatin do not occur in isolation. Chromatin-associated
proteins and their modification products form a highly interconnected network, and …
proteins and their modification products form a highly interconnected network, and …
Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation
P Jermann, L Hoerner, L Burger… - Proceedings of the …, 2014 - National Acad Sciences
Trimethylation of histone H3 at lysine 27 (H3K27me3) is a chromatin mark associated with
Polycomb-mediated gene repression. Despite its critical role in development, it remains …
Polycomb-mediated gene repression. Despite its critical role in development, it remains …
Resetting histone modifications during human parental-to-zygotic transition
Histone modifications regulate gene expression and development. To address how they are
reprogrammed in human early development, we investigated key histone marks in human …
reprogrammed in human early development, we investigated key histone marks in human …
Spatiotemporal DNA methylome dynamics of the developing mouse fetus
Cytosine DNA methylation is essential for mammalian development but understanding of its
spatiotemporal distribution in the developing embryo remains limited,. Here, as part of the …
spatiotemporal distribution in the developing embryo remains limited,. Here, as part of the …
Spatiotemporal DNA methylome dynamics of the developing mammalian fetus
Genetic studies have revealed an essential role for cytosine DNA methylation in mammalian
development. However, its spatiotemporal distribution in the developing embryo remains …
development. However, its spatiotemporal distribution in the developing embryo remains …
Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk
AB Brinkman, H Gu, SJJ Bartels, Y Zhang… - Genome …, 2012 - genome.cshlp.org
Cross-talk between DNA methylation and histone modifications drives the establishment of
composite epigenetic signatures and is traditionally studied using correlative rather than …
composite epigenetic signatures and is traditionally studied using correlative rather than …