In modern transplant and biomedicine, a proper understanding of both allo-and autoimmune
processes is of key importance to minimize acute and chronic graft failure and consecutive …

Today we know that both the humoral and the cellular arm of the immune system are
engaged in severe immunological challenges. A close interaction between B and T cells can …

Abstract “When Stem Cells Meet Immunology” has been the topic of the 21st annual “Nantes
Actualités en Transplantation” meeting (June 9-10, 2016, Nantes, France). This meeting …

Transplantation is the treatment of choice for end‐stage kidney, heart, lung, and liver
disease. Short‐term outcomes in solid‐organ transplantation are excellent, but long‐term …

Organ transplantation faces two major challenges. First, we need to urgently identify a
potentially inexhaustible source of organs. Second, we need to make immunosuppression …

Although major advances have been made in solid organ and hematopoietic stem cell
transplantation in the last 50 years, big challenges remain. This review outlines the current …

The whole field of hematological malignancies has experienced a huge breakthrough
during the past 40 years. Major methodological progress in cytogenetics (eg, fluorescence in …

Modern immunosuppressive armamentarium inadequately controls the humoral arm of
recipient immune response, which in turn plays a central role in the pathogenesis of chronic …

Alloimmunity driving rejection in the context of solid organ transplantation can be grossly
divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) …

The pathophysiology of antibody-mediated rejection (AMR) in solid organ transplants is
multifaceted and predominantly caused by antibodies directed against polymorphic donor …