We developed a (three-dimensional) 3D scaffold, we named HY-FIB, incorporating a force-
transmission band of braided hyaluronate embedded in a cell localizing fibrin hydrogel and …

At present, injuries or rupture of tendons are treated by surgical repair or conservative
approaches with unpredictable clinical outcome. Alternative strategies to repair tendon …

Hydrogels have been used extensively with various cell types in three-dimensional (3D)
culture, including with human mesenchymal stem cells (hMSCs). Here, we report on the use …

Mesenchymal stem cells derived from human bone marrow (hBM-MSCs) are utilized in
tendon tissue-engineering protocols while extra-embryonic cord-derived, including from …

Background Osteoarthritis (OA) is a degenerative joint disease affecting approximately 27
million Americans, and even more worldwide. OA is characterized by degeneration of …

Background High post-surgical failure rates following tendon injury generate high medical
costs and poor patient recovery. Cell-based tendon tissue engineering has the potential to …

Tendon and ligament (T/L) engineering is a growing area of research with potential to
address the inadequacies of current T/L defect treatments. Our group previously developed …

Currently available methods to treat articular cartilage defects still fail to demonstrate
satisfactory outcomes for many patients. Functional tissue engineering using human bone …

In this study, hMSCs encapsulated in a fibrin hydrogel containing heparinized NPs loaded
with TGF-β3 (100 ng/ml), or TGF-β3 (100 ng/ml) alone, were subjected to growth factor …

Using the microenvironment of healing bone tissue as inspiration, this study utilized fibrin
hydrogels combined with collagen type I and calcium phosphate ceramics to create a …