Helicobacter pylori is a human-pathogenic bacterial species that is subdivided
geographically, with different genotypes predominating in different parts of the world. Here …

Resistance to metronidazole (MTZ) in Helicobacter pylori is associated with mutations in
rdxA, encoding an oxygen-insensitive NADPH nitroreductase, and mutations in frxA …

The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in
metronidazole (MTZ) susceptibility and resistance has been controversial. Jeong et al.(J …

Metronidazole (Mtz) is a critical component of combination therapies that are used against
Helicobacter pylori, the major cause of peptic ulcer disease. Many H. pylori strains are Mtz …

Metronidazole (Mtz) is a critical ingredient of modern multidrug therapies for Helicobacter
pylori infection. Mtz resistance reduces the effectiveness of these combinations. Although …

We found that NCTC11637, the type strain of Helicobacter pylori, the causative agent of
peptic ulcer disease and an early risk factor for gastric cancer, is metronidazole resistant …

Metronidazole (Mtz) resistance in the gastric pathogen Helicobacter pylori is closely
associated with inactivation of the nitroreductase gene rdxA. In order to identify respective …

Metronidazole resistance is a key factor associated with Helicobacter pylori treatment failure.
Although this resistance is mainly associated with mutations in the rdxA and frxA genes, the …

Modern triple drug regimens are highly effective for treating Helicobacter pylori infection, but
bacterial resistance to one of the most effective antibiotics, metronidazole, is a serious and …

In Helicobacter pylori, the oxygen-insensitive nitroreductase RdxA is likely to activate
metronidazole (Mtz) by reduction and formation of cytotoxic intermediates. Mutations in rdxA …