Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of
energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone …

Objective To investigate whether mitochondrial function is altered in circulating immune cells
from calcium oxalate (CaOx) stone formers compared to healthy subjects. Materials and …

Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …

Monocytes/macrophages are thought to be recruited to the renal interstitium during calcium
oxalate (CaOx) kidney stone disease for crystal clearance. Mitochondria play an important …

Calcium oxalate monohydrate (COM) crystals, the major crystalline compound in kidney
stones, have been suggested to induce oxidative stress by overproduction of reactive …

Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in
mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed …

Calcium oxalate monohydrate (COM) crystals are the commonest component of kidney
stones. Oxalate and COM crystals in renal cells are thought to contribute to pathology via …

Hyperoxaluria-induced oxidative injury of renal tubular epithelial cell is a casual and
essential factor in kidney calcium oxalate (CaOx) stone formation. Autophagy has been …

Urolithiasis, a complex multifactorial disease, results from interactions between
environmental and genetic factors. Epidemiological studies have shown the association of …

The interactions between the main cellular sources of ROS, such as mitochondria and
NADPH oxidase, are known to play an imperative role in the pathogenesis of hyperoxaluria …