Follicle-stimulating hormone alleviates ovarian aging by modulating mitophagy-and glycophagy-based energy metabolism in hens

J Dong, C Guo, Z Yang, Y Wu, C Zhang - Cells, 2022 - mdpi.com
As a predominant hormone in the reproductive axis, follicle-stimulating hormone (FSH) is
known as the primary surviving factor for follicular growth. In this study, the alleviating effect …

Nobiletin Ameliorates Aging of Chicken Ovarian Prehierarchical Follicles by Suppressing Oxidative Stress and Promoting Autophagy

J Bai, X Wang, Y Chen, Q Yuan, Z Yang, Y Mi, C Zhang - Cells, 2024 - mdpi.com
With the increase in the age of laying chickens, the aging of follicles is accelerated, and the
reproductive ability is decreased. Increased oxidative stress and mitochondrial malfunction …

Metformin prevents follicular atresia in aging laying chickens through activation of PI3K/AKT and calcium signaling pathways

J Yao, Y Ma, S Zhou, T Bao, Y Mi… - Oxidative Medicine …, 2020 - Wiley Online Library
Increased follicular atresia occurs with aging and results in reduced fecundity in laying
chickens. Therefore, relieving follicular atresia of aging poultry is a crucial measure to …

FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells

H Xi, F Ren, Y Li, M Xian, L Wang, J Hu - Molecular and Cellular …, 2022 - Elsevier
Although the follicle-stimulating hormone (FSH) plays a vital role in male reproduction, the
molecular relationships among FSH, autophagy, and the secretory function of Sertoli cells …

FSH prevents porcine granulosa cells from hypoxia‐induced apoptosis via activating mitophagy through the HIF‐1α‐PINK1‐Parkin pathway

C Li, J Zhou, Z Liu, J Zhou, W Yao, J Tao… - The FASEB …, 2020 - Wiley Online Library
In developing follicles, the granulosa cells (GCs) live in a hypoxic environment due to the
devoid of blood supply. Upon hypoxic conditions, several types of mammalian cells have …

High doses of FSH induce autophagy in bovine ovarian granulosa cells via the AKT/mTOR pathway

X Tang, L Ma, S Guo, M Liang… - Reproduction in domestic …, 2021 - Wiley Online Library
Follicle‐stimulating hormone (FSH) plays a critical role in follicular growth and granulosa
cell function; however, the mechanism by which the aggressive stimulation of FSH leads to …

FSH promotes progesterone synthesis by enhancing autophagy to accelerate lipid droplet degradation in porcine granulosa cells

Q Liu, H Gao, F Yang, H Zhang, S Zeng - Frontiers in cell and …, 2021 - frontiersin.org
Little is known about the molecular relationships among follicle stimulating hormone (FSH),
lipid droplet (LD) degradation, and autophagy. In this study, we aimed to investigate the …

Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy

M Shen, Y Jiang, Z Guan, Y Cao, L Li, H Liu, S Sun - Autophagy, 2017 - Taylor & Francis
Oxidative stress-induced granulosa cell (GCs) death represents a common reason for
follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from …

The attenuating effect of the intraovarian bone morphogenetic protein 4 on age‐related endoplasmic reticulum stress in chicken follicular cells

J Yao, Y Ma, X Lin, S Zhou, Y Mi… - Oxidative Medicine and …, 2020 - Wiley Online Library
In the poultry, only less than 5% primordial follicles in the ovary can develop into the
prehierarchical follicles (PHFs) leading to progressive development, ovulation, and egg …

Protective effect of follicle-stimulating hormone on DNA damage of chicken follicular granulosa cells by inhibiting CHK2/p53

S Zhou, A Zhao, Y Wu, T Bao, Y Mi, C Zhang - Cells, 2022 - mdpi.com
The increase in follicular atresia and the decrease in the fecundity of laying hens occur with
the aging process. Therefore, the key measure for maintaining high laying performance is to …