The link between sex hormones and susceptibility to cardiac arrhythmias: from molecular basis to clinical implications

S Costa, AM Saguner, A Gasperetti, D Akdis… - Frontiers in …, 2021 - frontiersin.org
It is well-known that gender is an independent risk factor for some types of cardiac
arrhythmias. For example, males have a greater prevalence of atrial fibrillation and the …

Non-genomic action of sex steroid hormones and cardiac repolarization

J Kurokawa, T Furukawa - Biological and Pharmaceutical Bulletin, 2013 - jstage.jst.go.jp
Gender differences play a major role in the manifestation of cardiovascular disease
including cardiac arrhythmias. In particular, female sex is an independent risk factor for …

Regulation of cardiac ion channels via non-genomic action of sex steroid hormones: implication for the gender difference in cardiac arrhythmias

T Furukawa, J Kurokawa - Pharmacology & therapeutics, 2007 - Elsevier
Long QT syndrome (LQTS) is a disorder associated with prolonged electrocardiographic QT
intervals and the development of ventricular arrhythmias. LQTS occurs as a congenital form …

Sex differences in cardiac electrophysiology

U Ravens - Canadian journal of physiology and pharmacology, 2018 - cdnsciencepub.com
Women have a longer QT interval than men, which appears to evolve after puberty
suggesting that sex hormones have an influence on cardiac electrophysiology. Sex …

Sex differences in cardiac electrophysiology and clinical arrhythmias: epidemiology, therapeutics, and mechanisms

R Tadros, AT Ton, C Fiset, S Nattel - Canadian Journal of Cardiology, 2014 - Elsevier
Sex differences in cardiac electrophysiological properties and arrhythmias are evident in
epidemiologic and investigative studies as well as in daily patient care. At the …

Sex-related differences in cardiac channelopathies: implications for clinical practice

B Asatryan, L Yee, Y Ben-Haim, S Dobner… - Circulation, 2021 - Am Heart Assoc
Sex-related differences in prevalence, clinical presentation, and outcome of cardiac
channelopathies are increasingly recognized, despite their autosomal transmission and …

Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study

PC Yang, J Kurokawa, T Furukawa… - PLoS computational …, 2010 - journals.plos.org
Acute effects of sex steroid hormones likely contribute to the observation that post-pubescent
males have shorter QT intervals than females. However, the specific role for hormones in …

How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity

KE Odening, G Koren - Heart rhythm, 2014 - Elsevier
Gender differences in cardiac repolarization and the arrhythmogenic risk of patients with
inherited and acquired long QT syndromes are well appreciated clinically. Enhancing our …

Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes

J Kurokawa, M Kodama, CE Clancy… - Pharmacology & …, 2016 - Elsevier
Female sex is an independent risk factor for development of torsade de pointes (TdP)
arrhythmias not only in congenital long QT syndromes but also in acquired long QT …

Sex differences in heart: from basics to clinics

C Prajapati, J Koivumäki, M Pekkanen-Mattila… - European Journal of …, 2022 - Springer
Sex differences exist in the structure and function of human heart. The patterns of ventricular
repolarization in normal electrocardiograms (ECG) differ in men and women: men ECG …