[HTML][HTML] Beneficial immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1, 3-1, 6 Beta glucans in Duchenne muscular dystrophy …

K Raghavan, VD Dedeepiya, S Srinivasan… - IBRO Neuroscience …, 2023 - Elsevier
Background This exploratory case-control study is to evaluate the effects of supplementation
of Aureobasidium pullulans-N-163 strain produced 1, 3–1,− 6 beta glucan in young patients …

Disease-Modifying immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1, 3-1, 6 beta glucans in young boys with Duchenne muscular …

K Raghavan, VD Dedeepiya, S Srinivasan, S Pushkala… - medRxiv, 2021 - medrxiv.org
Background Duchenne muscular dystrophy (DMD) is an inherited neuromuscular disorder
causing progressive muscle weakness and premature death. Steroids remain the …

Efficacy of N-163 strain of Aureobasidium pullulans-produced beta-glucan in improving muscle strength and function in patients with Duchenne muscular dystrophy; …

K Raghavan, T Sivakumar, SS Bharatidasan… - medRxiv, 2023 - medrxiv.org
Duchenne muscular dystrophy (DMD) is a debilitating genetic disease that causes gradual
muscle weakening and early mortality. After a 45-day clinical pilot study and a pre-clinical …

[HTML][HTML] Efficacy of N-163 beta-glucan in beneficially improving biomarkers of relevance to muscle function in patients with muscular dystrophies in a pilot clinical study

K Raghavan, T Sivakumar, K Ichiyama… - Acta …, 2023 - ncbi.nlm.nih.gov
Background Muscular dystrophies other than Duchenne muscular dystrophy (DMD) are
genetic diseases characterized by increasing muscle weakness, loss of ambulation, and …

Randomised trial of Aureobasidium pullulans-produced beta 1,3-1,6-glucans in patients with Duchenne muscular dystrophy: Favourable changes in gut microbiota …

K Raghavan, VD Dedeepiya, N Yamamoto, N Ikewaki… - medRxiv, 2022 - medrxiv.org
Objective Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder that
leads to increasing muscle weakening and early death. Steroids, the standard treatment of …

Enhanced muscle regeneration in mdx mice, Duchenne muscular dystrophy animal model, proven by CD44 & MYH3 expression, on oral feeding of N-163 strain of …

S Preethy, S Sakamoto, T Higuchi, K Ichiyama… - biorxiv, 2023 - biorxiv.org
Introduction Duchenne muscular dystrophy (DMD) is a X-linked fatal myogenic disorder, in
which lack of dystrophin leads to significant fibrosis and a progressive loss of muscle mass …

[HTML][HTML] Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced β-glucan

S Preethy, Y Aoki, K Minegishi, M Iwasaki… - Scientific Reports, 2023 - nature.com
Recent advances in the management of Duchenne muscular dystrophy (DMD), such as
exon skipping and gene therapy, though have reached a clinical stage, the outcome at its …

[HTML][HTML] Extracellular polysaccharides purified (Polycan) from Aureobasidium pullulans SM‑2001 improves pathophysiology of dystrophin-deficient mdx mice

YS Kim, JM Lim, JS Shin, HJ Kim, KI Park… - Molecular & Cellular …, 2022 - Springer
Background Duchenne muscular dystrophy is a hereditary muscular disease involving
degeneration (ie atrophy and loss of muscle fibres) of skeletal muscles, including the …

[HTML][HTML] Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats

N Ikewaki, K Raghavan, VD Dedeepiya, S Vaddi… - Clinical Immunology …, 2021 - Elsevier
The beneficial immunomodulation effects of a biological response modifier glucan (BRMG)
produced by two strains of Aureobasidium pullulans, AFO-202 and N-163, have already …

[HTML][HTML] Assessing the use of the sGC stimulator BAY-747, as a potential treatment for duchenne muscular dystrophy

SM Krishnan, J Nordlohne, L Dietz… - International Journal of …, 2021 - mdpi.com
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder,
affecting one in 3500 to 5000 boys worldwide. The NO-sGC-cGMP pathway plays an …