Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High levels
of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are attributed …

Background Microsatellite instability (MSI) constitutes an important oncogenic molecular
pathway in colorectal cancer (CRC), representing approximately 15% of all colorectal …

Background Elevated microsatellite instability at selected tetranucleotide repeats (EMAST) is
a genetic signature identified in 60% of sporadic colon cancers and may be linked with …

BACKGROUND & AIMS:: Elevated microsatellite alterations at selected tetranucleotide
repeats (EMAST) occurs during microsatellite instability (MSI) that is not associated with …

Microsatellite instability (MSI) is a hallmark of hereditary nonpolyposis colorectal cancer, and
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …

DNA mismatch repair (MMR) function is critical for correcting errors coincident with
polymerase-driven DNA replication, and its proteins are frequent targets for inactivation …

The microsatellite instability (MSI) pathway is one of the important mutational pathways that
play a critical role in colorectal carcinogenesis. About 15% of colorectal cancers (CRCs) are …

Two microsatellite instability (MSI) phenotypes have been described in colorectal cancer
(CRC): MSI-H (instability at> 30% of the loci examined) and MSI-L (MSI at 1–30% of the loci …

Mutations in DNA mismatch repair genes (such as MLH1, MSH2 or MSH6) result in a failure
to repair errors in repetitive sequences, leading to microsatellite instability (MSI) of the …

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …