Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer
Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High levels
of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are attributed …
of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are attributed …
Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications
A Zaanan, K Meunier, F Sangar, JF Fléjou, F Praz - Cellular oncology, 2011 - Springer
Background Microsatellite instability (MSI) constitutes an important oncogenic molecular
pathway in colorectal cancer (CRC), representing approximately 15% of all colorectal …
pathway in colorectal cancer (CRC), representing approximately 15% of all colorectal …
Relationship of EMAST and microsatellite instability among patients with rectal cancer
B Devaraj, A Lee, BL Cabrera, K Miyai, L Luo… - Journal of …, 2010 - Elsevier
Background Elevated microsatellite instability at selected tetranucleotide repeats (EMAST) is
a genetic signature identified in 60% of sporadic colon cancers and may be linked with …
a genetic signature identified in 60% of sporadic colon cancers and may be linked with …
Microsatellite alterations at selected tetranucleotide repeats are associated with morphologies of colorectal neoplasias
SY Lee, H Chung, B Devaraj, M Iwaizumi, HS Han… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS:: Elevated microsatellite alterations at selected tetranucleotide
repeats (EMAST) occurs during microsatellite instability (MSI) that is not associated with …
repeats (EMAST) occurs during microsatellite instability (MSI) that is not associated with …
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers
SA Kuismanen, MT Holmberg, R Salovaara… - The American journal of …, 2000 - Elsevier
Microsatellite instability (MSI) is a hallmark of hereditary nonpolyposis colorectal cancer, and
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …
EMAST is a form of microsatellite instability that is initiated by inflammation and modulates colorectal cancer progression
JM Carethers, M Koi, SS Tseng-Rogenski - Genes, 2015 - mdpi.com
DNA mismatch repair (MMR) function is critical for correcting errors coincident with
polymerase-driven DNA replication, and its proteins are frequent targets for inactivation …
polymerase-driven DNA replication, and its proteins are frequent targets for inactivation …
hMSH6 Alterations in Patients with Microsatellite Instability-Low Colorectal Cancer
YR Parc, KC Halling, L Wang, ER Christensen… - Cancer research, 2000 - AACR
Two microsatellite instability (MSI) phenotypes have been described in colorectal cancer
(CRC): MSI-H (instability at> 30% of the loci examined) and MSI-L (MSI at 1–30% of the loci …
(CRC): MSI-H (instability at> 30% of the loci examined) and MSI-L (MSI at 1–30% of the loci …
Mismatch repair pathway: molecules, functions, and role in colorectal carcinogenesis
AS Sameer, S Nissar, K Fatima - European journal of cancer …, 2014 - journals.lww.com
The microsatellite instability (MSI) pathway is one of the important mutational pathways that
play a critical role in colorectal carcinogenesis. About 15% of colorectal cancers (CRCs) are …
play a critical role in colorectal carcinogenesis. About 15% of colorectal cancers (CRCs) are …
Clinical relevance of microsatellite instability in colorectal cancer
A De La Chapelle, H Hampel - Journal of Clinical Oncology, 2010 - ascopubs.org
Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …
[PDF][PDF] Importance of microsatellite instability (MSI) in colorectal cancer: MSI as a diagnostic tool
G Kurzawski, J Suchy, T Dębniak, J Kładny… - Annals of …, 2004 - academia.edu
Mutations in DNA mismatch repair genes (such as MLH1, MSH2 or MSH6) result in a failure
to repair errors in repetitive sequences, leading to microsatellite instability (MSI) of the …
to repair errors in repetitive sequences, leading to microsatellite instability (MSI) of the …