HPLC and LC–MS/MS-Based Quantitative Characterization of Related Substances Associated with Sotalol Hydrochloride

P Zhu, X Shen, X Wang, X Liu, Y Zhang, K Wang… - Molecules, 2024 - mdpi.com
In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were
herein identified with a novel gradient high-performance liquid chromatography (HPLC) …

A fast stability-indicating HPLC method for determination of sotalol hydrochloride in bulk powder and in dosage form

AA Abdelmonem, GH Ragab, HA Hashem… - Main Group …, 2016 - content.iospress.com
A novel stability-indicating HPLC method was developed and validated for quantitative
determination of sotalol-HCl in bulk powder and in tablets. Isocratic HPLC method, using a C …

Development of a validated spectrofluorimetric method for assay of sotalol hydrochloride in tablets and human plasma: application for stability-indicating studies

FA Ibrahim, AM El-Brashy, MI El-Awady… - Open …, 2019 - degruyter.com
The native fluorescence of sotalol hydrochloride (SOT) was used as a basis for establishing
a new method of analysis for SOT in tablets and spiked human plasma. The fluorescence of …

A simple and sensitive LC‐MS/MS method for the determination of sotalol in rat plasma

Z Feng, S Yu, W Liu, L Yang, Y Liu… - Biomedical …, 2015 - Wiley Online Library
A sensitive, rapid and robust HPLC method with tandem mass spectrometry (HPLC/MS/MS)
detection has been developed and validated for the quantification of sotalol in rat plasma …

Development and validation of high performance liquid chromatographic and UV-derivative spectrophotometric methods for the determination of sotalol hydrochloride …

MIRM Santoro, C Tsubone, FP Gomes… - Analytical …, 2008 - Taylor & Francis
High performance liquid chromatographic (HPLC) and UV derivative spectrophotometric
(UVDS) methods were developed and validated for the quantitative determination of sotalol …

Development of a gradient HPLC method for the simultaneous determination of sotalol and sorbate in oral liquid preparations using solid core stationary phase

L Matysova, O Zahalkova, S Klovrzova… - Journal of analytical …, 2015 - Wiley Online Library
A selective and sensitive gradient HPLC‐UV method for quantification of sotalol
hydrochloride and potassium sorbate in five types of oral liquid preparations was developed …

Determination of sotalol hydrochloride by reversed-phase high performance liquid chromatography

WH Wang, GS Zhao, WL Jiang, AX Zuo… - Se pu= Chinese Journal …, 2000 - europepmc.org
An RP-HPLC method for determination and detection of sotalol hydrochloride is described.
The baseline separation was achieved on ODS column within 15 minutes by using 0.1 …

Development an ion-pair liquid chromatographic method for determination of sotalol in plasma using a monolithic column

A Zarghi, SM Foroutan, A Shafaati… - Journal of pharmaceutical …, 2006 - Elsevier
A rapid and sensitive ion-pair HPLC method using a monolithic column and fluorescence
detection has been developed for quantification of sotalol in plasma. The assay enables the …

Development and validation of an automated method for the liquid chromatographic determination of sotalol in plasma using dialysis and trace enrichment on a cation …

P Chiap, A Ceccato, BM Buraglia, B Boulanger… - … of pharmaceutical and …, 2001 - Elsevier
A fully automated method for the determination of sotalol in human plasma was developed,
involving dialysis through a cellulose acetate membrane, clean-up and enrichment of the …

Fully automated LC method for the determination of sotalol in human plasma using restricted access material with cation exchange properties for sample clean-up

O Rbeida, B Christiaens, P Chiap, P Hubert… - … of pharmaceutical and …, 2003 - Elsevier
A simple and rapid fully automated bio-analytical method for the liquid chromatographic (LC)
determination of sotalol in human plasma has been described. The method is based on the …