A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

Systems biology based metabolic engineering for non-natural chemicals

A Biz, S Proulx, Z Xu, K Siddartha, AM Indrayanti… - Biotechnology …, 2019 - Elsevier
Production of chemicals in microorganisms is no longer restricted to products arising from
native metabolic potential. In this review, we highlight the evolution of metabolic engineering …

Synthesis of chemicals by metabolic engineering of microbes

X Sun, X Shen, R Jain, Y Lin, J Wang, J Sun… - Chemical society …, 2015 - pubs.rsc.org
Metabolic engineering is a powerful tool for the sustainable production of chemicals. Over
the years, the exploration of microbial, animal and plant metabolism has generated a wealth …

Manufacturing molecules through metabolic engineering

JD Keasling - Science, 2010 - science.org
Metabolic engineering has the potential to produce from simple, readily available,
inexpensive starting materials a large number of chemicals that are currently derived from …

Systems metabolic engineering of microorganisms for natural and non-natural chemicals

JW Lee, D Na, JM Park, J Lee, S Choi… - Nature chemical biology, 2012 - nature.com
Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of chemicals, fuels …

Coupling chemical and biological catalysis: a flexible paradigm for producing biobased chemicals

TJ Schwartz, BH Shanks, JA Dumesic - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Produce biobased chemicals using both chemical and biological catalysis.•Use
biological catalysis to convert sugars to de-functionalized platform molecules.•Upgrade …

De novo biosynthetic pathways: rational design of microbial chemical factories

KLJ Prather, CH Martin - Current opinion in biotechnology, 2008 - Elsevier
Increasing interest in the production of organic compounds from non-petroleum-derived
feedstocks, especially biomass, is a significant driver for the construction of new …

[HTML][HTML] Production of fuels and chemicals from biomass: condensation reactions and beyond

L Wu, T Moteki, AA Gokhale, DW Flaherty, FD Toste - Chem, 2016 - cell.com
Renewable resources and bio-based feedstocks may present a sustainable alternative to
petrochemical sources to satisfy modern society's ever-increasing demand for energy and …

Integration of heterogeneous and biochemical catalysis for production of fuels and chemicals from biomass

I Wheeldon, P Christopher, H Blanch - Current opinion in biotechnology, 2017 - Elsevier
The past decade has seen significant government and private investment in fundamental
research and process development for the production of biofuels and chemicals from …

[HTML][HTML] Synthetic biochemistry: the bio-inspired cell-free approach to commodity chemical production

JU Bowie, S Sherkhanov, TP Korman, MA Valliere… - Trends in …, 2020 - cell.com
Metabolic engineering efforts that harness living organisms to produce natural products and
other useful chemicals face inherent difficulties because the maintenance of life processes …