Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long …

Advanced in vitro kidney models are of great importance to the study of renal physiology and
disease. Kidney tubuloids can be established from primary cells derived from adult kidney …

In the past five years, pluripotent stem cell (PSC)-derived kidney organoids and adult stem
or progenitor cell (ASC)-based kidney tubuloids have emerged as advanced in vitro models …

Adult kidney organoids have been described as strictly tubular epithelia and termed
tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that …

Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …

The kidney is a vital organ that regulates the bodily fluid and electrolyte homeostasis via
tailored urinary excretion. Kidney injuries that cause severe or progressive chronic kidney …

Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …

The human kidney contains up to 2 million epithelial nephrons responsible for blood
filtration. Regenerating the kidney requires the induction of the more than 20 distinct cell …

The renal proximal tubule epithelium is responsible for active secretion of endogenous and
exogenous waste products from the body and simultaneous reabsorption of vital compounds …

Kidney organoids derived from human pluripotent stem cells have glomerular-and tubular-
like compartments that are largely avascular and immature in static culture. Here we report …