A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia

LM Jenkins, L Wang, H Rosen, S Weintraub - Brain, 2022 - academic.oup.com
Apathy and disinhibition are common and highly distressing neuropsychiatric symptoms
associated with negative outcomes in persons with dementia. This paper is a critical review …

Disease-specific profiles of apathy in Alzheimer's disease and behavioural-variant frontotemporal dementia differ across the disease course

G Wei, M Irish, JR Hodges, O Piguet, F Kumfor - Journal of Neurology, 2020 - Springer
Apathy is one of the most prevalent and disabling non-cognitive symptoms of dementia. This
loss of motivation and pervasive decline in goal-directed behaviour represents a core …

Apathy in Alzheimer's disease: A neurocircuitry based perspective

SF Mehak, AB Shivakumar, V Saraf… - Ageing Research …, 2023 - Elsevier
In addition to memory deficits and other cognitive disturbances, patients with Alzheimer's
disease (AD) experience neuropsychiatric symptoms, notably apathy, which is a state of …

Apathy associated with neurocognitive disorders: recent progress and future directions

KL Lanctôt, L Agüera-Ortiz, H Brodaty, PT Francis… - Alzheimer's & …, 2017 - Elsevier
Introduction Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's
disease and mild cognitive impairment. Although the definition of apathy is inconsistent in …

[HTML][HTML] The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and …

DC Steffens, M Fahed, KJ Manning, L Wang - Translational psychiatry, 2022 - nature.com
Apathy is a common condition that involves diminished initiative, diminished interest and
diminished emotional expression or responsiveness. It is highly prevalent in the context of a …

Apathy: a neurocircuitry model based on frontotemporal dementia

S Ducharme, BH Price, BC Dickerson - Journal of Neurology …, 2018 - jnnp.bmj.com
Apathy is a symptom shared among many neurological and psychiatric disorders. However,
the underlying neurocircuitry remains incompletely understood. Apathy is one of the core …

State of the science: apathy as a model for investigating behavioral and psychological symptoms in dementia

L Massimo, HC Kales… - Journal of the American …, 2018 - Wiley Online Library
Apathy is one of the most common and pervasive of the behavioral and psychological
symptoms of dementia (BPSDs). Apathy has profound consequences for morbidity, mortality …

The neuroimaging basis of apathy: Empirical findings and conceptual challenges

SE Starkstein, S Brockman - Neuropsychologia, 2018 - Elsevier
Apathy, usually defined as loss of motivation, is common in both neurodegenerative
conditions such as Alzheimer's disease, and acute neurological disorders such as stroke …

Apathy in Alzheimer's disease and frontotemporal dementia: distinct clinical profiles and neural correlates

F Kumfor, A Zhen, JR Hodges, O Piguet, M Irish - Cortex, 2018 - Elsevier
Objective Apathy is the most prevalent and disabling non-cognitive symptom of dementia
and affects 90% of patients across the disease course. Despite its pervasiveness, how …

[HTML][HTML] Apathy as a treatment target in Alzheimer's disease: implications for clinical trials

ME Mortby, L Adler, L Agüera-Ortiz, DR Bateman… - The American Journal of …, 2022 - Elsevier
Apathy is one of the most prevalent, stable and persistent neuropsychiatric symptom across
the neurocognitive disorders spectrum. Recent advances in understanding of …