Effect of L-carnitine on potassium dichromate-induced nephrotoxicity in rats: modulation of PI3K/AKT signaling pathway

AAA Salama, RE Mostafa… - Research in …, 2022 - journals.lww.com
Background and purpose: Kidney diseases impose significant global health challenges.
Potassium dichromate (PD) is a heavy metal frequently associated with nephrotoxicity. PD …

Reno-protective effect of nicorandil and pentoxifylline against potassium dichromate-induced acute renal injury via modulation p38MAPK/Nrf2/HO-1 and Notch1/TLR4 …

EAM El-Shoura, LA Abdelzaher, AAN Ahmed… - Journal of Trace …, 2024 - Elsevier
Background Occupational and environmental exposure to chromium compounds such as
potassium dichromate (PDC)(K 2 Cr 2 O 7) has emerged as a potential aetiologic cause for …

L‐carnitine reverses methotrexate‐induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC‐1α/Nrf2/HO‐1 axis

SM Radwan, M Alqulaly, MY Elsaeed… - Journal of Applied …, 2023 - Wiley Online Library
Methotrexate (MTX) is a chemotherapeutic agent used for treating several types of cancer as
well as psoriasis and rheumatoid arthritis, but its use is limited due to its nephrotoxicity. The …

The effects of L-carnitine on renal function and gene expression of caspase-9 and Bcl-2 in monosodium glutamate‐induced rats

F Koohpeyma, M Siri, S Allahyari, M Mahmoodi, F Saki… - BMC nephrology, 2021 - Springer
Background Monosodium glutamate (MSG) is frequently consumed as a flavor enhancer or
food additive. Possible damages induced by MSG effects on some organs have been stated …

Potential nephroprotective effects of l-carnitine against drug-induced nephropathy: a review of literature

A Jafari, S Dashti-Khavidaki, H Khalili… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Drug-induced nephrotoxicity (DIN) has been reported with a great number of
medications and contributes to∼ 20% of hospital admissions. l-carnitine owing to its …

L-carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway

J Ye, J Li, Y Yu, Q Wei, W Deng, L Yu - Regulatory peptides, 2010 - Elsevier
Oxidative stress has been considered as the possible mechanism of renal
ischemia/reperfusion injury. l-carnitine is an endogenous mitochondrial membrane …

[HTML][HTML] Protective effect of vitamin E and atorvastatin against potassium dichromate-induced nephrotoxicity in rats

HA Mehany, AM Abo-youssef, LA Ahmed… - Beni-Suef University …, 2013 - Elsevier
Potassium dichromate, a Cr (VI) compound, is the most toxic form of Cr (VI) and has been
demonstrated to induce nephrotoxicity associated with oxidative stress in humans and …

Metabolomic Changes and Protective Effect of L-Carnitine in Rat Kidney Ischemia/Reperfusion Injury

Y Liu, S Yan, C Ji, W Dai, W Hu, W Zhang… - Kidney and Blood …, 2012 - karger.com
Background: Although great progress has been made in the pathogenesis and treatment of
acute kidney injury (AKI), it still has high incidence and poor prognosis. The present study …

[HTML][HTML] L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta …

T Emran, NI Chowdhury, M Sarker, AK Bepari… - Biomedicine & …, 2021 - Elsevier
Brief introduction Myocardial infarction (MI) is a common manifestation of certain cardiac
diseases where oxidative stress and fibrosis aggravate the condition markedly. Main …

[PDF][PDF] Renoprotective effects of L-Carnitine in streptozotocin-induced diabetic nephropathy

H Zheng, S Piao, L Sun, H Zhao, J Jin, J Jin… - Int J Clin Exp …, 2018 - e-century.us
Aim: L-Carnitine (LC) exerts protective effects on various types of injuries. This study aimed
to investigate whether LC treatment would confer renoprotection in a rat model of …