Meals are the functional units of food intake in humans and mammals, and physiologic
approaches to understanding the controls of meal size have demonstrated that the presence …

The communication between the gut and the brain is important for the control of energy
homeostasis. In response to food intake, enteroendocrine cells secrete gut hormones, which …

Given the crucial role of the gastrointestinal tract and associated organs in handling nutrient
assimilation and metabolism, it has long been known that its communication with the brain is …

Food interacts with sensors all along the alimentary canal to provide the brain with
information regarding its composition, energy content, and beneficial effect. Vagal afferents …

Ingestive behavior is controlled by a complex interplay between signals conveying
availability of (1) potentially ingestible food in the environment,(2) digestible food in the …

The signaling systems underlying eating behavior control are complex. The current review
focuses on gastrointestinal (GI) signaling systems as physiological key functions for …

The gastrointestinal tract has its own “brain,” the enteric nervous system or ENS, that
executes routine housekeeping functions of digestion. The dorsal vagal complex in the …

Vago-vagal reflex control circuits in the dorsal vagal complex of the brainstem provide
overall coordination over digestive functions of the stomach, small intestine and pancreas …

We have established a method to investigate the range of mechanical, nutrient chemical and
peptidergic meal-related stimuli that may generate vagal afferent neurophysiological signals …

During a meal, multiple gastrointestinal sites are stimulated by ingested nutrients and their
digestion products, initiating local gastrointestinal actions and producing a variety of …