Over the last two decades, improved access to human islets and the development of human
islet distribution networks have enabled the use of millions of human islets in hundreds of …

Human islet research is providing new insights into human islet biology and diabetes, using
islets isolated at multiple US centers from donors with varying characteristics. This creates …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Recent years have seen an increased focus on human islet biology, and exciting findings in
the stem cell and genomic arenas highlight the need to define the key features of mature …

Detailed characterization of human pancreatic islets is key to elucidating the
pathophysiology of all forms of diabetes, especially type 2 diabetes. However, access to …

The human genome project and its search for factors underlying human diseases has
fostered a major human research effort. Therefore, unsurprisingly, in recent years we have …

The pancreatic islet secretes the hormones insulin and glucagon to regulate glucose
metabolism. To generate an adequate secretory response, islet endocrine cells must receive …

Emerging reports on the organization of the different hormone-secreting cell types (alpha,
glucagon; beta, insulin; and delta, somatostatin) in human islets have emphasized the …

Human islet research is crucial to understanding the cellular biology of the pancreas in
developing therapeutic options for diabetes patients and in attempting to prevent the …

Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To
identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for …