Drug repositioning in the treatment of malaria and TB
The emergence and spread of drug resistance in the malaria parasite Plasmodium
falciparum as well as multi-and extremely drug-resistant forms of Mycobacterium …
falciparum as well as multi-and extremely drug-resistant forms of Mycobacterium …
Novel rational drug design strategies with potential to revolutionize malaria chemotherapy
Efforts to develop an effective malaria vaccine are yet to be successful and thus
chemotherapy remains the mainstay of malaria control strategy. Plasmodium falciparum, the …
chemotherapy remains the mainstay of malaria control strategy. Plasmodium falciparum, the …
New leads for drug repurposing against malaria
Highlights•Eighteen FDA approved drugs identified for repurposing as antimalarials.•Drugs
classified based on safety of prescription to high-risk groups.•Identification of eleven drugs …
classified based on safety of prescription to high-risk groups.•Identification of eleven drugs …
[HTML][HTML] Drug targets for resistant malaria: historic to future perspectives
New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …
“Recycling” classical drugs for malaria
Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …
huge struggles made to date to fight this infection, in 2012 over half a million people were …
[HTML][HTML] Recent advances in malaria drug discovery
MA Biamonte, J Wanner, KG Le Roch - Bioorganic & medicinal chemistry …, 2013 - Elsevier
This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …
New hope in the fight against malaria?
T Rodrigues, R Moreira, F Lopes - Future Medicinal Chemistry, 2011 - Taylor & Francis
“… the severe malaria situation has encouraged the scientific community to try to find new
drugs to tackle this disease. In fact, several nonprofit, public–private partnerships such as …
drugs to tackle this disease. In fact, several nonprofit, public–private partnerships such as …
Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate
H Matthews, M Usman-Idris, F Khan, M Read… - Malaria journal, 2013 - Springer
Background Drug repurposing or repositioning refers to the usage of existing drugs in
diseases other than those it was originally used for. For diseases like malaria, where there is …
diseases other than those it was originally used for. For diseases like malaria, where there is …
Malaria medicines: a glass half full?
TNC Wells, RH Van Huijsduijnen… - Nature Reviews Drug …, 2015 - nature.com
Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
From hybrid compounds to targeted drug delivery in antimalarial therapy
R Oliveira, D Miranda, J Magalhaes, R Capela… - Bioorganic & medicinal …, 2015 - Elsevier
The discovery of new drugs to treat malaria is a continuous effort for medicinal chemists due
to the emergence and spread of resistant strains of Plasmodium falciparum to nearly all …
to the emergence and spread of resistant strains of Plasmodium falciparum to nearly all …