Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …

Numerous efforts to understand the functional roles of antibodies demonstrated that they can
protect against malaria. However, it is unclear which antibody responses are the best …

Determining an immunologic correlate of protection against Plasmodium falciparum malaria
has been the holy grail of natural infection studies, and sought after as an endpoint for …

Malaria continues to be one of the world's leading causes of mortality and morbidity. The
development of effective malaria vaccines would make an enormous contribution to …

After more than 50 years of intensive research and development, only one malaria vaccine
candidate,“RTS, S,” has progressed to Phase 3 clinical trials. Despite only partial efficacy …

Recent efforts in malaria control have led to marked reductions in malaria incidence.
However, new strategies are needed to sustain malaria elimination and eradication and …

Introduction: An effective malaria vaccine would be considered a milestone of modern
medicine, yet has so far eluded research and development efforts. This can be attributed to …

Combining key antigens from the different stages of the P. falciparum life cycle in the context
of a multi-stage-specific cocktail offers a promising approach towards the development of a …

Although epidemiological observations, IgG passive transfer studies and experimental
infections in humans all support the feasibility of developing highly effective malaria …

Malaria is one of the world's most important diseases, and an effective, licensed vaccine
would be a major public health tool. There is currently a surge in efforts to develop malaria …