Drug-induced liver injury (DILI) is one of the leading causes of liver failure and withdrawal of
drugs from the market. A poor understanding of the precipitating event aetiology and …

The idiosyncratic nature and poor prognosis of drug-induced liver injury (DILI) make this
type of reaction a major safety issue during drug development, as well as the most common …

Drug-induced liver injury (DILI) has become one of the major challenges of drug safety all
over the word. So far, about 1,100 commonly used drugs including the medications used …

Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly
because of its ability to present with a variety of phenotypes including that of autoimmune …

The innate immune response plays important roles in drug-induced liver injury (DILI) in both
the pathogenesis of the injury and its resolution. Drug-induced liver inflammation contributes …

The liver is an important target for foreign chemicals, such as drugs, which are metabolized
and excreted by the liver. Reactive metabolites, or in some cases parent drug, elicit a variety …

Drug-induced liver injury (DILI) has become a major topic in the field of Hepatology and
Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic …

Polymorphisms in genes encoding the enzymes and other differences in innate immunity in
drug metabolism can be responsible for the interindividual difference in susceptibility to …

The liver is frequently exposed to potentially toxic materials, and it is the primary site of
clearance of foreign agents, along with many innate and adaptive immune cells …

The liver is a unique organ with important roles in immune regulation and drug disposition.
Both of which are important in the pathogenesis of drug-induced liver injury (DILI). Being …