Diabetes and the brain: oxidative stress, inflammation, and autophagy

M Muriach, M Flores-Bellver… - … medicine and cellular …, 2014 - Wiley Online Library
Diabetes mellitus is a common metabolic disorder associated with chronic complications
including a state of mild to moderate cognitive impairment, in particular psychomotor slowing …

Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress

S Rosales-Corral, DX Tan… - … Medicine and Cellular …, 2015 - Wiley Online Library
There are several oxidative stress‐related pathways interconnecting Alzheimer's disease
and type II diabetes, two public health problems worldwide. Coincidences are so compelling …

Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease

FG De Felice, ST Ferreira - Diabetes, 2014 - Am Diabetes Assoc
A growing body of evidence supports an intriguing clinical/epidemiological connection
between Alzheimer disease (AD) and type 2 diabetes (T2D). T2D patients have significantly …

The role of type 2 diabetes in neurodegeneration

G Verdile, SJ Fuller, RN Martins - Neurobiology of disease, 2015 - Elsevier
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …

[HTML][HTML] Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

S Pugazhenthi, L Qin, PH Reddy - … acta (BBA)-molecular basis of disease, 2017 - Elsevier
Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most …

The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

E Barone, F Di Domenico, M Perluigi… - Free Radical Biology and …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

[HTML][HTML] Insulin signaling impairment in the brain as a risk factor in Alzheimer's disease

C Hölscher - Frontiers in aging neuroscience, 2019 - frontiersin.org
Type 2 diabetes is a risk factor for developing Alzheimer's disease (AD). The underlying
mechanism that links up the two conditions seems to be the de-sensitization of insulin …

Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies

BJ Dutta, S Singh, S Seksaria, GD Gupta… - Pharmacological …, 2022 - Elsevier
Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into
a major public health issue. Concerning about its secondary complications, a growing body …

Inside the diabetic brain: role of different players involved in cognitive decline

JM Gaspar, FI Baptista, MP Macedo… - ACS chemical …, 2016 - ACS Publications
Diabetes mellitus is the most common metabolic disease, and its prevalence is increasing. A
growing body of evidence, both in animal models and epidemiological studies, has …

[HTML][HTML] Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain

DA Butterfield, F Di Domenico, E Barone - Biochimica et Biophysica Acta …, 2014 - Elsevier
Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …