Defining omic-based biomarker signatures of metabolic dysfunction-associated steatotic liver disease (MASLD): in vitro studies

SC Kamble, P Ghosh - Current Opinion in Biomedical Engineering, 2024 - Elsevier
Recent years have seen considerable rise in the cases of non-alcoholic and alcohol-
associated/related liver disease. Though largely, a reversible condition in early stages, if left …

The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

N Perakakis, K Stefanakis, CS Mantzoros - Metabolism, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose
spectrum covers clinical, histological and pathophysiological developments ranging from …

[HTML][HTML] Transcriptomics reveal a molecular signature in the progression of nonalcoholic steatohepatitis and identifies PAI‑1 and MMP‑9 as biomarkers in in vivo and …

Y Zhao, M Yakufu, C Ma, B Wang… - Molecular Medicine …, 2023 - spandidos-publications.com
Nonalcoholic steatohepatitis (NASH) is emerging as the primary driver of liver disease-
induced fibrosis. The imperative need for noninvasive biomarkers to ascertain disease …

[HTML][HTML] Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity

CJ Pirola, S Sookoian - World journal of gastroenterology, 2018 - ncbi.nlm.nih.gov
This review intends to uncover how information from large-scale genetic profiling (whole
genome sequencing, and whole exome sequencing) of nonalcoholic fatty liver disease …

[HTML][HTML] Biomarker discovery for chronic liver diseases by multi-omics–a preclinical case study

D Veyel, K Wenger, A Broermann, T Bretschneider… - Scientific reports, 2020 - nature.com
Nonalcoholic steatohepatitis (NASH) is a major cause of liver fibrosis with increasing
prevalence worldwide. Currently there are no approved drugs available. The development …

[HTML][HTML] The gene expression signature of metabolic dysfunction-associated steatotic liver disease from a multiomics perspective

CJ Pirola, S Sookoian - Clinical and Molecular Hepatology, 2024 - ncbi.nlm.nih.gov
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and its severe clinical
form, metabolic dysfunctionassociated steatohepatitis (MASH), are chronic liver diseases …

[HTML][HTML] Exploring the Multifaceted Landscape of MASLD: A Comprehensive Synthesis of Recent Studies, from Pathophysiology to Organoids and Beyond

A Soto, C Spongberg, A Martinino, F Giovinazzo - Biomedicines, 2024 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a widespread contributor to chronic liver
disease globally. A recent consensus on renaming liver disease was established, and …

[HTML][HTML] RETRACTED: The OMICs Window into Nonalcoholic Fatty Liver Disease (NAFLD)

L Carulli, G Zanca, F Schepis, E Villa - Metabolites, 2019 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a common cause of hepatic abnormalities
worldwide. Nonalcoholic steatohepatitis (NASH) is part of the spectrum of NAFLD and leads …

A Precision Medicine Guided Approach to the Utilization of Biomarkers in MASLD

N Thakral, H Desalegn, LA Diaz… - Seminars in Liver …, 2024 - thieme-connect.com
The new nomenclature of metabolic dysfunction-associated steatotic liver disease (MASLD)
emphasizes a positive diagnosis based on cardiometabolic risk factors. This definition is not …

Non-alcoholic steatohepatitis: new insights from OMICS studies

C Martel, D Degli Esposti, A Bouchet… - Current …, 2012 - ingentaconnect.com
Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology characterized
by fat accumulation in a context of metabolic syndrome or insulin resistance. It can be …