Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain
R Sultana, M Perluigi, DA Butterfield - Free Radical Biology and Medicine, 2013 - Elsevier
Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …
Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics
R Sultana, M Perluigi, DA Butterfield - Antioxidants & redox signaling, 2006 - liebertpub.com
Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal
death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and …
death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and …
4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies
M Perluigi, R Coccia, DA Butterfield - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Among different forms of oxidative stress, lipid peroxidation comprises the
interaction of free radicals with polyunsaturated fatty acids, which in turn leads to the …
interaction of free radicals with polyunsaturated fatty acids, which in turn leads to the …
Redox proteomics identification of 4‐hydroxynonenal‐modified brain proteins in Alzheimer's disease: role of lipid peroxidation in Alzheimer's disease pathogenesis
M Perluigi, R Sultana, G Cenini… - PROTEOMICS …, 2009 - Wiley Online Library
Numerous studies have shown that neuronal lipids are highly susceptible to oxidative stress
including in those brain areas directly involved in the neurodegenerative process of …
including in those brain areas directly involved in the neurodegenerative process of …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Oxidative modification of brain proteins in Alzheimer's disease: perspective on future studies based on results of redox proteomics studies
R Sultana, DA Butterfield - Journal of Alzheimer's Disease, 2013 - content.iospress.com
Aging is the major risk factor associated with neurodegenerative diseases, including
Alzheimer's disease (AD). Until now no clear understanding of the mechanisms of initiation …
Alzheimer's disease (AD). Until now no clear understanding of the mechanisms of initiation …
Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain
DA Butterfield, F Di Domenico, AM Swomley… - Biochemical …, 2014 - portlandpress.com
Accumulation of oxidative damage is a common feature of neurodegeneration that, together
with mitochondrial dysfunction, point to the fact that reactive oxygen species are major …
with mitochondrial dysfunction, point to the fact that reactive oxygen species are major …
Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications
DA Butterfield, M Perluigi, T Reed… - Antioxidants & redox …, 2012 - liebertpub.com
Several studies demonstrated that oxidative damage is a characteristic feature of many
neurodegenerative diseases. The accumulation of oxidatively modified proteins may disrupt …
neurodegenerative diseases. The accumulation of oxidatively modified proteins may disrupt …
Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics
DA Butterfield, M Perluigi, R Sultana - European journal of pharmacology, 2006 - Elsevier
Alzheimer's disease, an age-related neurodegenerative disorder, is characterized clinically
by a progressive loss of memory and cognitive functions. Neuropathologically, Alzheimer's …
by a progressive loss of memory and cognitive functions. Neuropathologically, Alzheimer's …
Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this …
DA Butterfield, R Sultana - Journal of Alzheimer's Disease, 2007 - content.iospress.com
Alzheimer disease is a common age-related neurodegenerative disease characterized
pathologically by senile plaques, neurofibrillary tangles, synaptic disruption, and …
pathologically by senile plaques, neurofibrillary tangles, synaptic disruption, and …
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