During the research and development of new drugs directed at the central nervous system,
there is a considerable attrition rate caused by their hampered access to the brain by the …

The most important obstacle to the drug delivery into the brain is the presence of the blood–
brain barrier, which limits the traffic of substances between the blood and the nervous tissue …

The blood-brain barrier (BBB) is comprised of brain microvascular endothelial central
nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) …

Introduction: Drug targeting to brain by circumventing the physiological barriers is a
prerequisite for drugs acting on central nervous system (CNS) and therapeutic potential of …

The properties of the blood–brain barrier (BBB) are important considerations when
designing drugs to target or avoid the brain. In vivo models provide some of the most reliable …

The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

A wide variety of models have been developed over the years to predict blood–brain barrier
(BBB) penetration, most of them have focussed on predicting total concentrations of drug …

The passage of substances across the blood–brain barrier (BBB) is regulated in the cerebral
capillaries, which possess certain distinct different morphological and enzymatic properties …

The establishment of in vitro models of the BBB is significant for the evaluation of the
mechanism and permeability of drugs and their sustained-release formulations across the …

In vitro blood–brain barrier (BBB) models help predict brain uptake of potential central
nervous system drug candidates. Current in vitro models are composed of brain …