Around 0.75 million babies worldwide suffer from moderate or severe hypoxic-ischemic
encephalopathy (HIE) each year resulting in around 400,000 babies with …

Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with
its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard …

Context: Several interventions are available for the management of hypoxic ischemic
encephalopathy (HIE), but no studies have compared their relative efficacy in a single …

Introduction: Hypoxic ischemic encephalopathy (HIE) is the most important reason for
morbidity and mortality in term-born infants. Understanding pathophysiology of the brain …

Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that results in brain damage
in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major …

Abstract Purpose of Review Therapeutic hypothermia reduces death or disability in term and
near-term infants with moderate-severe hypoxic-ischemic encephalopathy. Nevertheless …

Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …

Importance Hypoxic-ischemic encephalopathy (HIE) occurs in 1 to 8 per 1000 live births in
developed countries. Historically, the clinician has had little to offer neonates with HIE other …

New knowledge of the pathophysiology and evolution of hypoxic-ischemic brain injuries has
made feasible interventions to improve clinical outcomes for newborns surviving birth …

Background Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major
cause of death and long-term disability in term born neonates. Up to 20,000 infants each …