Cobalt is a hazardous material that has harmful effects on neurotoxicity. Excessive exposure
to cobalt or inactivation of the unique proline isomerase Pin1 contributes to age-dependent …

Alzheimer disease (AD) is characterized neuropathologically by intracellular neurofibrillary
tangles (NFT) and of extracellular senile plaques (SP), the central core of which is amyloid …

Human overexposure to nickel (Ni) emanating from the increasing application of Ni
compounds in modern technology is a major public health concern. Nickel has been shown …

The unique proline isomerase Pin1 is pivotal for protecting against age-dependent
neurodegeneration in Alzheimer's disease (AD), with its inhibition providing a molecular link …

Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and
hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's …

Oxidative signaling and oxidative stress contribute to aging, cancer, and diseases resulting
from neurodegeneration. Pin1 is a proline isomerase that recognizes phosphorylated …

The environment, containing pollutants, toxins, and transition metals (copper, iron,
manganese, and zinc), plays a critical role in neurodegenerative disease development …

Early-stage Alzheimer's disease is characterized by the loss of dendritic spines in the
neocortex of the brain. This phenomenon precedes tau pathology, plaque formation, and …

Cobalt is an environmental toxicant, and excessive bodily exposure can damage the
nervous system. Particularly, our previous study reported that low-dose cobalt (significantly …

Pin1 protein is a peptidyl-prolyl cis-trans isomerase that modulates the activity of a range of
proteins involved in cell function. We and others have demonstrated neuronal Pin1 deficits …