Gastric diseases, including peptic ulcer disease and gastric cancer, affect 10% of the world's
population and are largely due to chronic Helicobacter pylori infection,,. Species differences …

Despite the global prevalence of gastric disease, there are few adequate models in which to
study the fundus epithelium of the human stomach. We differentiated human pluripotent …

The human stomach contains two primary domains: the corpus, which contains the fundic
epithelium, and the antrum. Each of these domains has distinct cell types and functions, and …

Studies in embryonic development have guided successful efforts to direct the differentiation
of human embryonic and induced pluripotent stem cells (PSCs) into specific organ cell types …

The constant regeneration of stomach epithelium is driven by long-lived stem cells,,, but the
mechanism that regulates their turnover is not well understood. We have recently found that …

Here we describe a protocol for generating 3D human intestinal tissues (called organoids) in
vitro from human pluripotent stem cells (hPSCs). To generate intestinal organoids …

Successful pluripotent stem cell differentiation methods have been developed for several
endoderm-derived cells, including hepatocytes, β-cells and intestinal cells. However …

LGR5 marks resident adult epithelial stem cells at the gland base in the mouse pyloric
stomach, but the identity of the equivalent human stem cell population remains unknown …

Wnt–β-catenin signalling plays a pivotal role in the homeostasis of the intestinal epithelium
by promoting stem cell renewal,. In the small intestine, epithelial Paneth cells secrete Wnt …

Epithelial organoids, such as those derived from stem cells of the intestine, have great
potential for modelling tissue and disease biology,,–. However, the approaches that are …