Miniaturized X-ray powder diffraction assay (MixRay) for quantitative kinetic analysis of solvent-mediated phase transformations in pharmaceutics
W Kirchmeyer, O Grassmann, N Wyttenbach… - … of pharmaceutical and …, 2016 - Elsevier
Many pharmaceutical compounds exhibit polymorphism, which may result in solvent-
mediated phase transformations. Since the polymorphic form has an essential influence on …
mediated phase transformations. Since the polymorphic form has an essential influence on …
X-ray powder diffractometry in combination with principal component analysis–a tool for monitoring solid state changes
K Kogermann, P Veski, J Rantanen… - European Journal of …, 2011 - Elsevier
In this study a combined approach of analysing structural changes and elucidating the
kinetics of the phase transformations by X-ray powder diffractometry (XRPD) and Raman …
kinetics of the phase transformations by X-ray powder diffractometry (XRPD) and Raman …
An overview of recent studies on the analysis of pharmaceutical polymorphs
Pharmaceutical solids are well known to be able to exist in different solid-state forms and
there are a wide variety of solid-state analytical techniques available to characterize …
there are a wide variety of solid-state analytical techniques available to characterize …
Quantification, mechanism, and mitigation of active ingredient phase transformation in tablets
NK Thakral, V Ragoonanan… - Molecular …, 2013 - ACS Publications
Model tablet formulations containing thiamine hydrochloride [as a nonstoichiometric hydrate
(NSH)] and dicalcium phosphate dihydrate (DCPD) were prepared. In intact tablets, the …
(NSH)] and dicalcium phosphate dihydrate (DCPD) were prepared. In intact tablets, the …
Tableting process-induced solid-state polymorphic transition
Background Polymorphism is that a substance exists into more than two crystalline forms
with different molecular arrangements and/or conformations. It has been reported that the …
with different molecular arrangements and/or conformations. It has been reported that the …
Quantitative determination of polymorphic composition in intact compacts by parallel-beam X-ray powder diffractometry II: data correction for analysis of phase …
PLD Wildfong, NA Morley, MD Moore… - Journal of pharmaceutical …, 2005 - Elsevier
An analytical, non-destructive method using parallel-beam transmission powder X-ray
diffractometry (PXRD) is presented for in situ whole compact detection and quantification of …
diffractometry (PXRD) is presented for in situ whole compact detection and quantification of …
The applicability of powder X-ray diffraction to the quantification of drug substance polymorphs using a model organic system
WC Kidd, P Varlashkin, C Li - Powder Diffraction, 1993 - cambridge.org
With a new emphasis on the control of polymorphism in pharmaceutical production, the
need for methods to quantify polymorphic forms has arisen. Techniques using X-ray powder …
need for methods to quantify polymorphic forms has arisen. Techniques using X-ray powder …
Solubility measurement of polymorphic compounds via the pH-metric titration technique
AF Fioritto, SN Bhattachar, JA Wesley - International journal of …, 2007 - Elsevier
In drug development, the thermodynamically most stable form of a compound is preferred
because metastable forms are prone to transform to the stable form during processing …
because metastable forms are prone to transform to the stable form during processing …
Use of glancing angle X-ray powder diffractometry to depth-profile phase transformations during dissolution of indomethacin and theophylline tablets
S Debnath, P Predecki, R Suryanarayanan - Pharmaceutical research, 2004 - Springer
Purpose. The purpose of this study was (i) to develop glancing angle x-ray powder
diffractometry (XRD) as a method for profiling phase transformations as a function of tablet …
diffractometry (XRD) as a method for profiling phase transformations as a function of tablet …
Extension of the dissolution-precipitation model for kinetic elucidation of solvent-mediated polymorphic transformations
P Jakubiak, F Schuler, R Alvarez-Sánchez - European Journal of …, 2016 - Elsevier
Thorough understanding and control of the different crystal forms of a drug product is key for
fine chemistry and materials science; it ultimately determines the product's physicochemical …
fine chemistry and materials science; it ultimately determines the product's physicochemical …
相关搜索
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