Many pharmaceutical compounds exhibit polymorphism, which may result in solvent-
mediated phase transformations. Since the polymorphic form has an essential influence on …

In this study a combined approach of analysing structural changes and elucidating the
kinetics of the phase transformations by X-ray powder diffractometry (XRPD) and Raman …

Pharmaceutical solids are well known to be able to exist in different solid-state forms and
there are a wide variety of solid-state analytical techniques available to characterize …

Model tablet formulations containing thiamine hydrochloride [as a nonstoichiometric hydrate
(NSH)] and dicalcium phosphate dihydrate (DCPD) were prepared. In intact tablets, the …

Background Polymorphism is that a substance exists into more than two crystalline forms
with different molecular arrangements and/or conformations. It has been reported that the …

An analytical, non-destructive method using parallel-beam transmission powder X-ray
diffractometry (PXRD) is presented for in situ whole compact detection and quantification of …

With a new emphasis on the control of polymorphism in pharmaceutical production, the
need for methods to quantify polymorphic forms has arisen. Techniques using X-ray powder …

In drug development, the thermodynamically most stable form of a compound is preferred
because metastable forms are prone to transform to the stable form during processing …

Purpose. The purpose of this study was (i) to develop glancing angle x-ray powder
diffractometry (XRD) as a method for profiling phase transformations as a function of tablet …

Thorough understanding and control of the different crystal forms of a drug product is key for
fine chemistry and materials science; it ultimately determines the product's physicochemical …