Neurons have extensive processes and communication between those processes and the
cell body is crucial to neuronal function and survival. Thus, neurons are uniquely dependent …

Many major human neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies …

The intracellular transport of organelles along an axon is crucial for the maintenance and
function of a neuron. Anterograde axonal transport has a role in supplying proteins and …

Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …

A core pathology central to most neurodegenerative diseases is the misfolding, fibrillization
and aggregation of disease proteins to form the hallmark lesions of specific disorders. The …

Many neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins …

Axonal transport is the process whereby motor proteins actively navigate microtubules to
deliver diverse cargoes, such as organelles, from one end of the axon to the other, and is …

In contrast to most eukaryotic cells, neurons possess long, highly branched processes called
axons and dendrites. In large mammals, such as humans, some axons reach lengths of over …

Because of the extremely polarized morphology, the proper functioning of neurons largely
relies on the efficient cargo transport along the axon. Axonal transport defects have been …

Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …