Vaginal extracellular vesicles impair fertility in endometriosis by favoring Th17/Treg imbalance and inhibiting sperm activity

Z Zhang, Y Xiong, H Jiang, Q Wang… - Journal of Cellular …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) play a key role in various diseases. However, their effect on
endometriosis (EMs)‐associated infertility is poorly understood. We co‐cultured EVs from …

Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor

H Wang, Y Lin, R Chen, Y Zhu, H Wang, S Li… - …, 2024 - academic.oup.com
Seminal extracellular vesicles (EVs) contain different subgroups that have diverse effects on
sperm function. However, the effect of seminal EVs—especially their subgroups—on …

[HTML][HTML] Role of Endometrial Extracellular Vesicles in Mediating Cell-to-Cell Communication in the Uterus: A Review

JR Beal, Q Ma, IC Bagchi, MK Bagchi - Cells, 2023 - mdpi.com
There are several critical events that occur in the uterus during early pregnancy which are
necessary for the establishment and maintenance of pregnancy. These events include …

[HTML][HTML] Extracellular vesicles: Mediators of embryo-maternal crosstalk during pregnancy and a new weapon to fight against infertility

M Das, V Kale - European Journal of Cell Biology, 2020 - Elsevier
In modern-day life, infertility is one of the major issues that can affect an individual, both
physically and psychologically. Several anatomical, physiological, and genetic factors might …

[HTML][HTML] The emerging roles and therapeutic potential of extracellular vesicles in infertility

G Zhou, Y Gu, F Zhou, M Zhang, G Zhang… - Frontiers in …, 2021 - frontiersin.org
Infertility is becoming much more common and affects more couples. The past years
witnessed the rapid development of the diagnosis and treatment upon infertility, which give …

Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation

R Machtinger, LC Laurent… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND Extracellular vesicles (EVs) are membrane-bound vesicles, found in
biofluids, that carry and transfer regulatory molecules, such as microRNAs (miRNAs) and …

Endometrial extracellular vesicles of recurrent implantation failure patients inhibit the proliferation, migration, and invasion of HTR8/SVneo cells

C Liu, L Li, M Wang, S Shui, H Yao, C Sui… - Journal of Assisted …, 2021 - Springer
Purpose Endometrial extracellular vesicles are essential in regulating trophoblasts' function.
This study aims to investigate whether endometrial extracellular vesicles (EVs) from …

In vitro decidualisation of human endometrial stromal cells is enhanced by seminal fluid extracellular vesicles

H Rodriguez-Caro, R Dragovic, M Shen… - Journal of …, 2019 - Taylor & Francis
Extracellular vesicles are highly abundant in seminal fluids and have a known role
enhancing sperm function. Clinical pregnancy rates after IVF treatment are improved after …

[HTML][HTML] Trophoblast derived extracellular vesicles specifically alter the transcriptome of endometrial cells and may constitute a critical component of embryo-maternal …

K Godakumara, J Ord, F Lättekivi… - Reproductive Biology …, 2021 - Springer
Background The period of time when the embryo and the endometrium undergo significant
morphological alterations to facilitate a successful implantation—known as “window of …

Extracellular vesicles and female reproduction

R Machtinger, AA Baccarelli, H Wu - Journal of Assisted Reproduction and …, 2021 - Springer
Extracellular vesicles (EVs) are nano-sized membrane bound complexes that have been
identified as a mean for intercellular communication between cells and tissues both in …