The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Macrophages are the first immune cells in the developing embryo and have a central role in
organ development, homeostasis, immunity and repair. Over the last century, our …

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue …

Macrophages are versatile cells of the hematopoietic system that display remarkable
functional diversity encompassing innate immune responses, tissue development, and …

Tissue-resident macrophages are present in most tissues with developmental, self-renewal,
or functional attributes that do not easily fit into a textbook picture of a plastic and …

Highlights•We review the potential impact of cellular origin on the function of
macrophages.•We discuss the recent evidence for macrophages plasticity.•We also highlight …

Macrophages have protective roles in immunity to pathogens, tissue development,
homeostasis and repair following damage. Maladaptive immunity and inflammation provoke …

Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

The explosion of new information in recent years on the origin of macrophages in the steady-
state and in the context of inflammation has opened up numerous new avenues of …