New Insights into the Identification of Metabolites and Cytokines Predictive of Outcome for Patients with Severe SARS-CoV-2 Infection Showed Similarity with Cancer

S Costantini, G Madonna, E Di Gennaro… - International Journal of …, 2023 - mdpi.com
SARS-CoV-2 infection is characterized by several clinical manifestations, ranging from the
absence of symptoms to severe forms that necessitate intensive care treatment. It is known …

Metabolic predictors of COVID-19 mortality and severity: A Survival Analysis

AM Abdallah, A Doudin, TO Sulaiman, O Jamil… - Frontiers in …, 2024 - frontiersin.org
Introduction The global healthcare burden of COVID-19 pandemic has been unprecedented
with a high mortality. Metabolomics, a powerful technique, has been increasingly utilized to …

Metabolic signatures associated with severity in hospitalized COVID-19 patients

J Marín-Corral, J Rodríguez-Morató… - International journal of …, 2021 - mdpi.com
The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the
metabolic pathways that are altered early with viral infection and their association with …

Metabolic profiling during COVID-19 infection in humans: Identification of potential biomarkers for occurrence, severity and outcomes using machine learning

GA Elgedawy, M Samir, NS Elabd, HH Elsaid, M Enar… - Plos one, 2024 - journals.plos.org
Background After its emergence in China, the coronavirus SARS-CoV-2 has swept the
world, leading to global health crises with millions of deaths. COVID-19 clinical …

Biological and clinical factors contributing to the metabolic heterogeneity of hospitalized patients with and without COVID-19

A D'alessandro, T Thomas, IJ Akpan, JA Reisz… - Cells, 2021 - mdpi.com
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide
challenge. The present large study sought to understand independent and overlapping …

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

H Blasco, C Bessy, L Plantier, A Lefevre, E Piver… - Scientific reports, 2020 - nature.com
The biological mechanisms involved in SARS-CoV-2 infection are only partially understood.
Thus we explored the plasma metabolome of patients infected with SARS-CoV-2 to search …

Immunometabolic signatures predict risk of progression to sepsis in COVID-19

AS Herrera-Van Oostdam, JE Castañeda-Delgado… - PLoS …, 2021 - journals.plos.org
Viral sepsis has been proposed as an accurate term to describe all multisystemic
dysregulations and clinical findings in severe and critically ill COVID-19 patients. The …

The serum metabolome of moderate and severe COVID-19 patients reflects possible liver alterations involving carbon and nitrogen metabolism

M Caterino, M Costanzo, R Fedele, A Cevenini… - International journal of …, 2021 - mdpi.com
COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical
sequelae and deaths, in the context of a world pandemic. The infection of the highly …

Diagnostic, prognostic and mechanistic biomarkers of COVID-19 identified by mass spectrometric metabolomics

M Bourgin, S Durand, G Kroemer - Metabolites, 2023 - mdpi.com
A number of studies have assessed the impact of SARS-CoV-2 infection and COVID-19
severity on the metabolome of exhaled air, saliva, plasma, and urine to identify diagnostic …

Integrated metabolic and inflammatory signatures associated with severity of, fatality of, and recovery from COVID-19

LG Gardinassi, CP Servian, GS Lima… - Microbiology …, 2023 - Am Soc Microbiol
Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been
associated with physiological alterations that provide insights into the pathogenesis of the …