Association of obesity-related metabolic disruptions with cancer risk and outcome

AE Lohmann, PJ Goodwin, RT Chlebowski… - Journal of Clinical …, 2016 - ascopubs.org
Over the past 40 years, the prevalence of obesity has increased epidemically worldwide,
which raises significant concerns regarding public health and the associated economic …

Obesity and cancer: a current overview of epidemiology, pathogenesis, outcomes, and management

S Pati, W Irfan, A Jameel, S Ahmed, RK Shahid - Cancers, 2023 - mdpi.com
Simple Summary Obesity has been linked to several common cancers including breast,
colorectal, esophageal, kidney, gallbladder, uterine, pancreatic, and liver cancer. Obesity …

Translating mechanism-based strategies to break the obesity− cancer link: a narrative review

LA Smith, CH O'Flanagan, LW Bowers, EH Allott… - Journal of the Academy …, 2018 - Elsevier
Prevalence of obesity, an established risk factor for many cancers, has increased
dramatically over the past 50 years in the United States and across the globe. Relative to …

Obesity and cancer mechanisms: cancer metabolism

BD Hopkins, MD Goncalves, LC Cantley - Journal of clinical oncology, 2016 - ascopubs.org
Obesity is a risk factor for cancer development and is associated with poor prognosis in
multiple tumor types. The positive energy balance linked with obesity induces a variety of …

Physiological and environmental factors affecting cancer risk and prognosis in obesity

PFS Etet, L Vecchio, AHN Kamdje, PN Mimche… - Seminars in Cancer …, 2023 - Elsevier
Obesity results from a chronic excessive accumulation of adipose tissue due to a long-term
imbalance between energy intake and expenditure. Available epidemiological and clinical …

Obesity and cancer: local and systemic mechanisms

NM Iyengar, CA Hudis… - Annual review of …, 2015 - annualreviews.org
Obesity is a leading modifiable risk factor for the development of several epithelial
malignancies. In addition to increasing risk, obesity also confers worse prognosis for many …

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

EE Calle, R Kaaks - Nature Reviews Cancer, 2004 - nature.com
The prevalence of obesity is rapidly increasing globally. Epidemiological studies have
associated obesity with a range of cancer types, although the mechanisms by which obesity …

Obesity and cancer: overview of mechanisms

NL Nock, NA Berger - Cancer and energy balance, epidemiology and …, 2010 - Springer
This chapter provides an overview of the putative pathophysiological mechanisms
explaining the positive association between obesity and various cancers. After presenting …

A weighty problem: metabolic perturbations and the obesity-cancer link

CH O'Flanagan, LW Bowers… - … molecular biology and …, 2015 - degruyter.com
Obesity is an established risk factor for several cancers, including breast, colon, endometrial,
ovarian, gastric, pancreatic and liver, and is increasingly a public health concern. Obese …

Obesity and cancer risk: Emerging biological mechanisms and perspectives

KI Avgerinos, N Spyrou, CS Mantzoros, M Dalamaga - Metabolism, 2019 - Elsevier
Continuously rising trends in obesity-related malignancies render this disease spectrum a
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …