Gliomas are the most frequent type of tumor in the central nervous system, which exhibit
properties that make their treatment difficult, such as cellular infiltration, heterogeneity, and …

Background The aggressive, invasive and treatment resistant nature of glioblastoma makes
it one of the most lethal cancers in humans. Total surgical resection is difficult, and a …

Primary brain tumors, in particular, glioblastoma multiforme (GBM), continue to have dismal
survivability despite advances in treating other neoplasms. The goal of new anti-glioma …

DNA damage response (DDR) comprising DNA repair and cell-cycle checkpoint pathways,
is considered as a protective process that maintains the integrity of the genome. However …

Despite improvements in therapeutic strategies, glioblastoma (GB) remains one of the most
lethal cancers. The presence of the blood–brain barrier, the infiltrative nature of the tumor …

Despite surgical resection and genotoxic treatment with ionizing radiation and the DNA
alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in …

The importance of DNA repair as a resistance mechanism in gliomas, the most aggressive
form of brain tumor, is a clinically relevant topic. Recent studies show that not all cells are …

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

Glioblastoma (GBM), the most prevalent type of primary intrinsic brain cancer in adults,
remains universally fatal despite maximal therapy, including radiotherapy and …

The incorporation of radiotherapy into multimodality treatment plans has led to significant
improvements in glioma patient survival. However, local recurrence from glioma resistance …