Activated protein C resistance determined with a thrombin generation‐based test predicts for venous thrombosis in men and women

G Tans, A van Hylckama Vlieg… - British journal of …, 2003 - Wiley Online Library
Activated protein C (APC) resistance, determined with a thrombin‐generation‐based APC
resistance test, may explain risk differences of venous thrombosis in users of second‐and …

Hormone replacement therapy and acquired resistance to activated protein C: results of a randomized, double‐blind, placebo‐controlled trial

E Høibraaten, MC Mowinckel… - British journal of …, 2001 - Wiley Online Library
Recent studies suggest that low‐dose oral contraceptives may cause acquired resistance to
activated protein C (APC). The aims of this study were to determine whether hormone …

Resistance to activated protein C in healthy women taking oral contraceptives

O Olivieri, S Friso, F Manzato, A Guella… - British Journal of …, 1995 - Wiley Online Library
Resistance to activated protein C (APC) is at present considered the most frequent
laboratory abnormality in patients with deep‐vein thrombosis. An increased risk for venous …

[HTML][HTML] Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients

RPM Lensen, FR Rosendaal, T Koster, CF Allaart… - Blood, 1996 - Elsevier
Both activated protein C (APC) resistance and protein C deficiency are associated with an
increased risk for venous thrombosis. To assess their tendencies to venous thrombosis, we …

A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis

MCH de Visser, FR Rosendaal… - Blood, The Journal of …, 1999 - ashpublications.org
Activated protein C (APC) resistance caused by the factor V Leiden mutation is associated
with an increased risk of venous thrombosis. We investigated whether a reduced response …

Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second‐and third‐generation oral contraceptives

J Rosing, G Tans, GAF Nicolaes… - British journal of …, 1997 - Wiley Online Library
Epidemiological studies have shown that women who use third‐generation oral
contraceptives (OC) containing desogestrel, gestodene or norgestimate have a higher risk of …

Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test

J Curvers, MCLGD Thomassen… - Thrombosis and …, 2002 - thieme-connect.com
Several hereditary and acquired risk factors for venous thromboembolism (VTE) are
associated with impaired down-regulation of thrombin formation via the protein C pathway …

The VITA project: phenotypic resistance to activated protein C and FV Leiden mutation in the general population

A Tosetto, F Rodeghiero, E Missiaglia… - Thrombosis and …, 1997 - thieme-connect.com
Resistance to activated protein C (APC) has been recently identified as a common
abnormality of the clotting system that significantly increases the risk of venous …

[HTML][HTML] Impact of progestagens on activated protein C (APC) resistance among users of oral contraceptives

M Alhenc‐Gelas, G Plu‐Bureau, S Guillonneau… - Journal of thrombosis …, 2004 - Elsevier
Oral contraceptive (OC) use is associated with an increased risk of venous
thromboembolism. Previous data reported higher thrombotic risk in women using third …

Acquired APC resistance and oral contraceptives: differences between two functional tests

J Curvers, MCLGD Thomassen… - British journal of …, 1999 - Wiley Online Library
Resistance to activated protein C (APC) is often associated with a mutation in factor V (factor
VLeiden). Individuals without factor VLeiden who exhibit a response in functional APC …