Zinc supplement reverses short-term memory deficit in sodium benzoate-induced neurotoxicity in male Wistar rats by enhancing anti-oxidative capacity via Nrf 2 up …

OO Akintoye, AJ Ajibare, MA Folawiyo… - Behavioural Brain …, 2023 - Elsevier
Sodium benzoate (SB) is a commonly-used food preservative, with a controversial report to
its neurological benefit and toxicity. Zinc (Zn) is a trace element that plays a crucial role in …

[HTML][HTML] Selenium and zinc alleviate quaternary metal mixture-induced neurotoxicity in rats by inhibiting oxidative damage and modulating the expressions of NF-kB …

C Dike, CN Orish, AN Ezejiofor, A Cirovic… - IBRO Neuroscience …, 2023 - Elsevier
Background This study evaluated the potential protective effects of Zn and Se in the
cerebellum and cerebral cortex, two fundamentally important brain regions, in albino rats …

Sodium benzoate induces neurobehavioral deficits and brain oxido‐inflammatory stress in male Wistar rats: Ameliorative role of ascorbic acid

FO Asejeje, BO Ajayi, MA Abiola… - … of Biochemical and …, 2022 - Wiley Online Library
Background Sodium benzoate (SB) is a widely used food preservative. However, excessive
intake of a high dose of SB poses a risk of neurotoxicity. Ascorbic acid (AA) is a naturally …

Betaine ameliorates depressive-like behaviors in zinc oxide nanoparticles exposed mice

M Jeyhoonabadi, S Alimoahmmadi… - … Trace Element Research, 2022 - Springer
The aim of the current study was to determine protective effects of betaine on depressive-like
behaviors in zinc oxide nanoparticles (ZnO NPs) exposed mice. Forty male mice randomly …

Prevention of neurotoxicity and cognitive impairment induced by zinc nanoparticles by oral administration of saffron extract

E Hamdi, AB Muñiz‐Gonzalez, S Hidouri… - Journal of Animal …, 2023 - Wiley Online Library
The accumulation of relatively higher dose of zinc oxide nanoparticles in brain was reported
to produce neurotoxicity. Indeed, nanoparticles have a high ability to penetrate biological …

Alterations of bio-elements, oxidative, and inflammatory status in the zinc deficiency model in rats

U Doboszewska, B Szewczyk, M Sowa-Kućma… - Neurotoxicity …, 2016 - Springer
Our previous study showed that dietary zinc restriction induces depression-like behavior
with concomitant up-regulation of the N-methyl-d-aspartate receptor (NMDAR). Because …

Examining the Influence of Zinc Oxide Nanoparticles and Bulk Zinc Oxide on Rat Brain Functions: a Comprehensive Neurobehavioral, Antioxidant, Gene Expression …

AA Goma, AR Salama, HG Tohamy, RR Rashed… - … Trace Element Research, 2024 - Springer
The study aimed to assess the impact of zinc oxide nanoparticles (ZnONPs) on rats'
neurobehavior compared to bulk zinc oxide (BZnO). Thirty male Sprague-Dawley rats were …

Selenium and zinc protect against heavy metal mixture-induced, olfactory bulb and hippocampal damage by augmenting antioxidant capacity and activation of Nrf2 …

EU Ikpeama, CN Orish, AN Ezejiofor… - International Journal …, 2023 - Taylor & Francis
Purpose/aim of the study Heavy metals and metalloids have been implicated in
neurodenerative diseases. Present study has evaluated the potential protective effects of Se …

Zinc modulates aluminium-induced oxidative stress and cellular injury in rat brain

N Singla, DK Dhawan - Metallomics, 2014 - academic.oup.com
Dysregulation of metal homeostasis has been perceived as one of the key factors in the
progression of neurodegeneration. Aluminium (Al) has been considered as a major risk …

The effects of acute administration of zinc oxidenanoparticles on long term memory in the presence and absence of vitamin C in adult male rat

M Kesmati, A Vahdati, SE Hoseini - Advances in Environmental …, 2014 - go.gale.com
Background and Objectives: Despite the wide spread use of zinc oxide nanoparticles (Nano
zinc oxide) in the medical and industry, a comprehensive study has been done on the effects …