[HTML][HTML] Single-cell transcriptome profiling of the human endometrium of patients with recurrent implantation failure

ZZ Lai, Y Wang, WJ Zhou, Z Liang, JW Shi, HL Yang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Introduction: Despite great advances in assisted reproductive technology (ART), recurrent
implantation failure (RIF) cannot be effectively avoided. Notably, cellular characteristics and …

Integrative analyses of uterine transcriptome and microRNAome reveal compromised LIF-STAT3 signaling and progesterone response in the endometrium of patients …

Y Choi, HR Kim, EJ Lim, M Park, JA Yoon, YS Kim… - PloS one, 2016 - journals.plos.org
Intimate two-way interactions between the implantation-competent blastocyst and receptive
uterus are prerequisite for successful embryo implantation. In humans, recurrent/repeated …

A comparison of transcriptomic profiles in endometrium during window of implantation between women with unexplained recurrent implantation failure and recurrent …

J Huang, H Qin, Y Yang, X Chen, J Zhang… - …, 2017 - rep.bioscientifica.com
The endometrium becomes receptive to the embryo only in the mid-luteal phase, but not in
the other stages of the menstrual cycle. Endometrial factors play an important role in …

The role of transcriptomic biomarkers of endometrial receptivity in personalized embryo transfer for patients with repeated implantation failure

A He, Y Zou, C Wan, J Zhao, Q Zhang, Z Yao… - Journal of translational …, 2021 - Springer
Background Window of implantation (WOI) displacement is one of the endometrial origins of
embryo implantation failure, especially repeated implantation failure (RIF). An accurate …

Potential marker pathways in the endometrium that may cause recurrent implantation failure

E Bastu, I Demiral, T Gunel, E Ulgen… - Reproductive …, 2019 - journals.sagepub.com
The aim of this prospective cohort study was to identify altered biologic processes in the
endometrium that may be potential markers of receptive endometrium in patients with …

[HTML][HTML] Recurrent implantation failure is a pathology with a specific transcriptomic signature

N Macklon - Fertility and sterility, 2017 - Elsevier
Recurrent implantation failure (RIF) is a source of distress and frustration to both patients
and their clinicians. In the absence of clinically useful tests, the therapeutic approach has …

A proteome approach reveals differences between fertile women and patients with repeated implantation failure on endometrial level—does hCG render the …

AP Bielfeld, SJ Pour, G Poschmann, K Stühler… - International Journal of …, 2019 - mdpi.com
Background: The molecular signature of endometrial receptivity still remains barely
understood, especially when focused on the possible benefit of therapeutical interventions …

Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure

C Shi, HJ Han, LJ Fan, J Guan, XB Zheng, X Chen… - Human …, 2018 - Taylor & Francis
High endometrial receptivity in the window of implantation (WOI) is essential for successful
implantation. However, a diagnostic tool with high specificity for impaired endometrial …

Screening and identification of endometrial proteins as novel potential biomarkers for repeated implantation failure

C Wang, Y Feng, WJ Zhou, ZJ Cheng, MY Jiang… - PeerJ, 2021 - peerj.com
Inadequate endometrial receptivity may be responsible for the low implantation rate of
transferred embryos in in vitro fertilization (IVF) treatments. Patients with repeated …

Human endometrial transcriptome and progesterone receptor cistrome reveal important pathways and epithelial regulators

RA Chi, T Wang, N Adams, S Wu… - The Journal of …, 2020 - academic.oup.com
Context Poor uterine receptivity is one major factor leading to pregnancy loss and infertility.
Understanding the molecular events governing successful implantation is hence critical in …