Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used
widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as …

A recent estimate suggests roughly 70percent of current lead compounds in modern drug
discovery derive directly from the natural products, many of which are glycosylated bacterial …

Glycosylation is a successful strategy to alter the pharmacological properties of small
molecules, and it has emerged as a unique approach to expand the chemical space of …

The bioactivity of many natural products including valuable antibiotics and anticancer
therapeutics depends on their sugar moieties. Changes in the structures of these sugars can …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Covering: up to March 2012 Oligo-, polysaccharides, and glycoconjugates are a relevant
part of the bioactive components of the natural products exploited in therapeutics …

Glycosylated natural products have served as reliable platforms for the development of
many existing front-line drugs. In an effort to explore the contribution of the sugar …

Glycosylation is a prominent strategy to optimize the pharmacokinetic and
pharmacodynamic properties of drug-like small-molecule scaffolds by modulating their …

Glycodiversification of natural products is an effective strategy for small molecule drug
development. Recently, improved methods for chemo-enzymatic synthesis of glycosyl …

The natural flavonoids, especially their glycosides, are the most abundant polyphenols in
foods and have diverse bioactivities. The biotransformation of flavonoid aglycones into their …