Sepsis is a systemic inflammatory response syndrome during infection. Therapeutic agents
are essential to protect the host from sepsis. Ovocalyxin-36 (OCX-36) is a chicken eggshell …

The avian eggshell membranes are essential elements in the fabrication of the calcified
shell as a defense against bacterial penetration. Ovocalyxin-36 (OCX-36) is an abundant …

The avian eggshell is a composite biomaterial composed of noncalcifying eggshell
membranes and the overlying calcified shell matrix. The shell is deposited in a uterine fluid …

The microbiological safety of avian eggs is a major concern for the poultry industry and for
consumers due to the potential for severe impacts on public health. Innate immune defense …

The chicken egg possesses physical and chemical barriers to protect the embryo from
pathogens. OCX-36 (ovocalyxin-36) was suggested to be a 36 kDa eggshell-specific protein …

The initial phase of sepsis is characterized by massive inflammatory cytokine production that
contributes to multisystem organ failure and death. Costimulatory molecules are a class of …

Complement and the TLR family constitute two important branches of innate immunity. We
previously showed attenuating effects on inflammation and thromogenicity by inhibiting the …

Lipopolysaccharide (LPS) plays a critical role in the pathogenesis of sepsis due to gram-
negative bacterial infections. Therefore, LPS-neutralizing molecules could have important …

Endotoxin, or lipopolysaccharide (LPS), is responsible for pathogenesis of infections
induced by Gram-negative bacteria, such as E. coli. The cellular response to LPS is …

The looped host defense peptide CLP-19 is derived from a highly functional core region of
the Limulus anti-LPS factor and exerts robust anti-LPS activity by directly interacting with …