Monitoring changes of signaling molecules and metabolites with high temporal resolution is
key to understanding dynamic biological systems. Here, we use directed evolution to …

Cyclic diguanylate (c-di-GMP) is a ubiquitous second messenger that regulates a wide
range of biological processes in bacteria, including motility, surface attachment, virulence …

Abstract Cyclic-di-GMP (c-di-GMP) is an important second messenger in bacteria which
regulates the bacterial transition from motile to sessile phase and also plays a major role in …

Spying on cGMP with FRET | Nature Methods Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Cyclic di-GMP (c-di-GMP) has emerged as a prominent intracellular messenger that
coordinates biofilm formation and pathogenicity in many bacterial species. Developing …

Second messenger signaling networks allow cells to sense and adapt to changing
environmental conditions. In bacteria, the nearly ubiquitous second messenger molecule …

Bacteria colonize highly diverse and complex environments, from gastrointestinal tracts to
soil and plant surfaces. This colonization process is controlled in part by the intracellular …

The widespread bacterial second messenger bis‐(3′‐5′)‐cyclic diguanosine
monophosphate (c‐di‐GMP) is an important regulator of biofilm formation, virulence and cell …

Intracellular signaling enzymes drive critical changes in cellular physiology and gene
expression, but their endogenous activities in vivo remain highly challenging to study in real …

For many years the surprising multiplicity, signal input diversity, and output specificity of c-di-
GMP signaling proteins has intrigued researchers studying bacterial second messengers …