The poor prognosis of patients with aggressive and invasive cancers combined with toxic
effects and short half-life of currently available treatments necessitate development of more …

OBJECTIVE: We sought to explore the dual-targeted antitumor effects of membrane-
spanned, tumor necrosis factor-related, apoptosis-inducing ligand (TRAIL)-engineered …

Tumor targeting by genetically modified mesenchymal stromal/stem cells (MSCs) carrying
anti-cancer molecules represents a promising cell-based strategy. We previously showed …

Therapeutically engineered stem cells (SC) are emerging as an effective tumor-targeted
approach for different cancer types. However, the assessment of the long-term fate of …

Adenovirus-mediated gene therapies against brain tumors have been limited by the difficulty
in tracking glioma cells infiltrating the brain parenchyma. Human umbilical cord blood …

Glioblastoma is among the most aggressive and treatment resistant of all human cancers.
Conventional therapeutic approaches are unsuccessful because of diffuse infiltrative …

Mesenchymal stem cells (MSCs) have an extensive migratory capacity for gliomas, which is
comparable to that of neural stem cells. Among the various types of MSCs, human adipose …

Therapeutically engineered stem cells have shown promise for glioblastoma multiforme
(GBM) therapy; however, key preclinical studies are urgently needed for their clinical …

Cancer is a leading cause of mortality throughout the world and new treatments are urgently
needed. Recent studies suggest that bone marrow–derived mesenchymal stem cells (MSC) …

Adipose-derived mesenchymal stromal/stem cells (AD-MSC) may offer efficient tools for cell-
based gene therapy approaches. In this study, we evaluated whether AD-MSC could deliver …